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T7165

Sigma-Aldrich

Tyrphostin 23

≥98%

Sinônimo(s):

(3,4-Dihydroxybenzylidene)malononitrile, RG-50810

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About This Item

Fórmula empírica (Notação de Hill):
C10H6N2O2
Número CAS:
118409-57-7
Peso molecular:
186.17
Número MDL:
MFCD00133899
Código UNSPSC:
12352200
ID de substância PubChem:
24278041
NACRES:
NA.77

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fonte biológica

synthetic (organic)

Ensaio

≥98%

Formulário

powder

potência

35 μM IC50

solubilidade

DMSO: soluble 50 mg/mL, clear, yellow to brownish-yellow

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Oc1ccc(cc1O)\C=C(\C#N)C#N

InChI

1S/C10H6N2O2/c11-5-8(6-12)3-7-1-2-9(13)10(14)4-7/h1-4,13-14H

chave InChI

VTJXFTPMFYAJJU-UHFFFAOYSA-N

Informações sobre genes

human ... CDK2(1017)

Aplicação

Tyrphostin 23 can be used as a tyrosine kinase inhibitor for studying rat ghrelin-induced MAPK stimulation in GH3 cells[1]. Tyrphostin 23 has also been used to analyze its effects on secretoneurin (SN)-induced chemotaxis of neutrophils[2].

Ações bioquímicas/fisiológicas

Tyrphostin 23 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain[3],[4].

Características e benefícios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
MKCQ1112
MKCP4881
MKCF7678
MKCD6227
MKBW4965V

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Mikyung Yang et al.
American journal of physiology. Lung cellular and molecular physiology, 294(5), L1007-L1012 (2008-03-18)
We assessed the roles of the protein kinase C (PKC) and the tyrosine kinase (TK) signaling pathways in regulating capacitative calcium entry (CCE) in human pulmonary artery smooth muscle cells (PASMCs) and investigated the effects of intravenous anesthetics (midazolam, propofol
Gennadii Petrovich Gusev et al.
Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, 180(3), 385-391 (2009-11-26)
Recently (Agalakova and Gusev in J Comp Physiol 179:443-450, 2009), we demonstrated that the activity of K-Cl cotransport (KCC) in frog red blood cells is inhibited under stimulation of protein kinase C (PKC) with phorbol ester PMA (12-myristate-13-acetate). Present work
Doan-Trung Luu et al.
The Plant journal : for cell and molecular biology, 69(5), 894-905 (2011-11-05)
The constitutive cycling of plant plasma membrane (PM) proteins is an essential component of their function and regulation under resting or stress conditions. Transgenic Arabidopsis plants that express GFP fusions with AtPIP1;2 and AtPIP2;1, two prototypic PM aquaporins, were used
Thanos Ghelis et al.
Plant physiology, 148(3), 1668-1680 (2008-09-05)
Protein tyrosine (Tyr) phosphorylation plays a central role in many signaling pathways leading to cell growth and differentiation in animals. Tyr phosphorylated proteins have been detected in higher plants, and the roles of protein Tyr phosphatases and protein Tyr kinases
Sheung Kwan Lam et al.
The Plant journal : for cell and molecular biology, 60(5), 865-881 (2009-08-28)
Brefeldin A (BFA) is a useful tool for studying protein trafficking and identifying organelles in the plant secretory and endocytic pathways. At low concentrations (5-10 microg ml(-1)), BFA caused both the Golgi apparatus and trans-Golgi network (TGN), an early endosome
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