Pular para o conteúdo
Merck
Todas as fotos(2)

Documentos Principais

Visualizar Toda a Documentação

T182

Sigma-Aldrich

Tyrphostin A9

solid

Sinônimo(s):

Malonoben, [[3,5-bis(1,1-Dimethylethyl)-4-hydroxyphenyl]methylene]propanedinitrile

Faça loginpara ver os preços organizacionais e de contrato

Selecione um tamanho

5 MG
R$ 1.046,00
25 MG
R$ 2.371,00

R$ 1.046,00

Previsão de entrega em15 de abril de 2025

Solicite uma grande encomenda
Todas as fotos(2)

Selecione um tamanho

Alterar visualização
5 MG
R$ 1.046,00
25 MG
R$ 2.371,00

About This Item

Fórmula empírica (Notação de Hill):
C18H22N2O
Número CAS:
10537-47-0
Peso molecular:
282.38
Número MDL:
MFCD00209853
Código UNSPSC:
51111800
ID de substância PubChem:
24278069
NACRES:
NA.77

R$ 1.046,00

Previsão de entrega em15 de abril de 2025

Solicite uma grande encomenda

fonte biológica

synthetic (organic)

Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

solid

cor

yellow

pf

139-140 °C

solubilidade

ethanol: 20 mg/mL
DMSO: <25 mg/mL
H2O: insoluble

cadeia de caracteres SMILES

CC(C)(C)c1cc(\C=C(\C#N)C#N)cc(c1O)C(C)(C)C

InChI

1S/C18H22N2O/c1-17(2,3)14-8-12(7-13(10-19)11-20)9-15(16(14)21)18(4,5)6/h7-9,21H,1-6H3

chave InChI

MZOPWQKISXCCTP-UHFFFAOYSA-N

Informações sobre genes

human ... EGFR(1956) , ORAI1(84876) , PDGFRA(5156) , PDGFRB(5159)
mouse ... Eef2k(13631) , Prkaca(18747) , Prkca(18750) , Src(20779)

Aplicação

Tyrphostin A9 can be used for inhibiting tyrosine kinase functions in C2C12 cells[1]. It has also been used to disrupt membrane potential in mammalian cells[2].

Ações bioquímicas/fisiológicas

Tyrphostin A9 is a PDGF receptor tyrosine kinase inhibitor that can induce apoptosis in cancer cells[3], inhibit the growth of vascular smooth cells[4] and block calcium release-dependent phosphorylations[5].

Características e benefícios

This compound is a featured product for Kinase Phosphatase Biology research. Click here to discover more featured Kinase Phosphatase Biology products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Nota de preparo

Tyrphostin A9 is soluble in ethanol at 20 mg/ml, in DMSO at a concentration less than 25 mg/ml. It is insoluble in water.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H301 + H311

Classificações de perigo

Acute Tox. 3 Dermal - Acute Tox. 3 Oral

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
MKCV7328
MKCT9315
MKCS3755
MKCR8771
MKCH0037

Não está vendo a versão correta?

Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.

Pesquise por COA

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

So Jung Park et al.
Biochemical and biophysical research communications, 408(3), 465-470 (2011-04-30)
Mitochondria dynamics controls not only their morphology but also functions of mitochondria. Therefore, an imbalance of the dynamics eventually leads to mitochondria disruption and cell death. To identify specific regulators of mitochondria dynamics, we screened a bioactive chemical compound library
Naveen Kumar et al.
Journal of virology, 85(6), 2818-2827 (2011-01-07)
Host signaling pathways play important roles in the replication of influenza virus, but their functional effects remain to be characterized at the molecular level. Here we identify two receptor tyrosine kinase inhibitors (RTKIs) of the tyrphostin class that exhibit robust
J Thyberg
European journal of cell biology, 76(1), 33-42 (1998-07-03)
To proliferate, vascular smooth muscle cells first convert from a contractile to a synthetic phenotype. Earlier studies indicate that this process is supported by fibronectin and accelerated by platelet-derived growth factor (PDGF). Here, the mechanisms in this transition were further
R Marhaba et al.
Journal of immunology (Baltimore, Md. : 1950), 157(4), 1468-1473 (1996-08-15)
The mechanism by which calcium-depleted intracellular stores may trigger an external calcium influx through a calcium release-activated channel was investigated by analyzing the effects of several protein tyrosine kinase inhibitors on calcium movements in Jurkat T cells. Tyrphostin A9, an
Naveen Kumar et al.
Antimicrobial agents and chemotherapy, 55(12), 5553-5559 (2011-09-21)
We have previously reported that two receptor tyrosine kinase inhibitors (RTKIs), called AG879 and tyrphostin A9 (A9), can each block the replication of influenza A virus in cultured cells. In this study, we further characterized the in vitro antiviral efficacies
Exibir todos os documentos relacionados

Questions

Reviews

No rating value

Active Filters

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica