This product may be stored at -20°C in aliquots at least until the recommended retest date published in the Certificate of Analysis. Avoid repeated freeze/thaw cycles.
T1952
Trichostatin A, Ready Made Solution
5 mM in DMSO, from Streptomyces sp.
Sinônimo(s):
TSA, [R-(E,E)]-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
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200 μL
R$ 733,00
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200 μL
R$ 733,00
About This Item
Fórmula empírica (Notação de Hill):
C17H22N2O3
Número CAS:
Peso molecular:
302.37
Código UNSPSC:
12352202
NACRES:
NA.32
Produtos recomendados
fonte biológica
Streptomyces sp.
Nível de qualidade
Ensaio
≥98% (HPLC)
Formulário
DMSO solution
concentração
5 mM in DMSO
técnica(s)
cell culture | mammalian: suitable
espectro de atividade do antibiótico
fungi
neoplastics
Modo de ação
enzyme | inhibits
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
cadeia de caracteres SMILES
N(O)C(=O)\C=C\C(=C\C(C)C(=O)c1ccc(cc1)N(C)C)\C
InChI
1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+
chave InChI
RTKIYFITIVXBLE-WKWSCTOISA-N
Descrição geral
Trichostatin A is a compound of primary hydroxamic acid.[1]
Aplicação
Trichostatin A, ready-made solution has been used:
- as a histone deacetylase inhibitor to study its effect on transcriptome changes by stem cell testing[2]
- to inhibit histone deacetylase (HDAC) class I, II, or III in primary pituitary cell cultures and to investigate insulin control of endogenous human growth hormone gene (hGH)[3]
- to treat cells for the HDAC inhibition experiments[4]
Ações bioquímicas/fisiológicas
Trichostatin A (TSA) is a Streptomyces metabolite, which specifically inhibits mammalian histone deacetylase at a nanomolar concentration and causes accumulation of highly acetylated histone molecules in mammalian cells. For that reason, trichostatin A is a tool to study the consequences of histone acetylation in vivo. Trichostatin A induces cell differentiation, cell cycle arrest, reversal of transformed cells morphology, and apoptosis and is able to modulate transcription. TSA has been used to establish a new cloning technique, which increases the success rates for mouse cloning.
Trichostatin A is a Streptomyces metabolite, which specifically inhibits mammalian histone deacetylase.
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Nº do produto
Descrição
Preços
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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