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B5887

Sigma-Aldrich

Sodium butyrate

≥98.5% (GC)

Sinônimo(s):

Butyric acid sodium salt

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250 MG
R$ 295,00
1 G
R$ 1.014,00
5 G
R$ 3.173,00

R$ 295,00

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250 MG
R$ 295,00
1 G
R$ 1.014,00
5 G
R$ 3.173,00

About This Item

Fórmula linear:
CH3CH2CH2COONa
Número CAS:
156-54-7
Peso molecular:
110.09
Beilstein:
3629439
Número CE:
205-857-6
Número MDL:
MFCD00002816
Código UNSPSC:
12352107
ID de substância PubChem:
24891873
NACRES:
NA.25

R$ 295,00

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fonte biológica

synthetic (organic)

Nível de qualidade

200

Ensaio

≥98.5% (GC)

Formulário

powder

condição de armazenamento

(Tightly closed. Dry.
Keep in a dry place. )

técnica(s)

DNA amplification: suitable
cell based assay: suitable
inhibition assay: suitable

cor

white

pf

250-253 °C (lit.)

solubilidade

water: 100 mg/mL, clear to slightly hazy, colorless

traços de cátion

Na: 19.8-22.0% (anhydrous)

adequação

suitable for DNA precipitation

aplicação(ões)

cell analysis
life science and biopharma
lipidomics

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

[Na+].CCCC([O-])=O

InChI

1S/C4H8O2.Na/c1-2-3-4(5)6;/h2-3H2,1H3,(H,5,6);/q;+1/p-1

chave InChI

MFBOGIVSZKQAPD-UHFFFAOYSA-M

Informações sobre genes

mouse ... ENSMUSG00000061062(15181)

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Aplicação

Sodium butyrate has been used:
  • as a component in homogenization and immunoprecipitation buffer for HDAC inhibition in fly embryos and insect s2 cells.[1]
  • as histone deacetylase inhibitor in breast cancer cell line MDA-MB-231, analysed by cell viability assay and viral replication assay.[2]
  • to enhance the production of recombinant tissue-plasminogen activator (t-PA) in Chinese hamster ovary (CHO) cells in a bioreactor.[3]

Ações bioquímicas/fisiológicas

Sodium butyrate is a short-chain fatty acid that inhibits histone deacetylase (HDAC) in the millimolar range.[1][2] Decreases Ca2+ release from intracellular stores. Induces apoptosis in several cell lines. Sodium butyrate induces the production of recombinant protein in Chinese hamster ovary (CHO) cells and other human cell lines. Sodium butyrate affects the proteome and gene expression pathways in the cells. It represses cell cycle related genes and modifies the genes involved in cell metabolism and apoptosis.[3]

Atenção

Hygroscopic

Outras notas

For additional information on our range of Biochemicals, please complete this form.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H302,H315,H319

Classificações de perigo

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

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Certificados de análise (COA)

Lot/Batch Number
0000408364
0000408364
0000407727
0000407728
0000407727

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Sigma-Aldrich

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Na-butyrate sustains energetic states of metabolism and t-PA productivity of CHO cells
McMurray-Beaulieu V, et al.
Journal of Bioscience and Bioengineering, 108(2), 160-167 (2009)
Histone deacetylase Rpd3 regulates olfactory projection neuron dendrite targeting via the transcription factor Prospero
Tea JS, et al.
The Journal of Neuroscience, 30(29), 9939-9946 (2010)
Histone deacetylase inhibitors improve the replication of oncolytic herpes simplex virus in breast cancer cells
Cody JJ, et al.
PLoS ONE, 9(3), e92919-e92919 (2014)
Jiangping He et al.
Nature communications, 10(1), 34-34 (2019-01-04)
The majority of mammalian genomes are devoted to transposable elements (TEs). Whilst TEs are increasingly recognized for their important biological functions, they are a potential danger to genomic stability and are carefully regulated by the epigenetic system. However, the full
Ras Trokovic et al.
Stem cell research, 15(1), 254-262 (2015-06-23)
Somatic cells can be reprogrammed into induced pluripotent stem cells (iPSC) by the forced expression of the transcription factors OCT4, SOX2, KLF4 and c-MYC. Pluripotent reprogramming appears as a slow and inefficient process because of genetic and epigenetic barriers of
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Questions

1–3 of 3 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

  3. I would like to know which is the recommended solvent to make dilutions with Sodium butyrate B5887, they are meant for long-term storage.

    1 answer

    1. This product is soluble in water at 100 mg/mL. The filter-sterilized solution is stable for up to 2 years at 2-8°C as indicated for the 500mM prepared solution, product TR-1008.

      Helpful?

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