SML3826

LW-3-254

≥98% (HPLC)

• Sinônimo(s): (3aR,4R,4aR,5aS,6S,6aS)-2-(4-(2-(3,5-dichlorophenyl)-2-oxoethoxy)phenyl)-4,4a,5,5a,6,6a-hexahydro-4,6-ethenocyclopropa[f]isoindole-1,3(2H,3aH)-dione, Analog 13
• Fórmula empírica (Notação de Hill): C₂₅H₁₉Cl₂NO₄
• Peso molecular: 468.33
• Código UNSPSC: 51111800
• Código UNSPSC: 12352200
• NACRES: NA.21

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to beige
• solubilidade: DMSO: 2 mg/mL, clear
• temperatura de armazenamento: -10 to -25°C

Descrição

Ações bioquímicas/fisiológicas

LW-3-254, a derivative of MM0299, is an orally bioavailable and blood-brain barrier penetrant, selective and potent inhibitor of lanosterol synthase (LSS) that exhibits anti-glioblastoma activity. LW-3-254 stimulates 24(S),25-epoxycholesterol (EPC) synthesis in GBM tumors, which induces toxicity in glioma stem-like cells. It potently inhibits Mut6 (Glioblastoma stem-like cells) cell growth by depleting cellular cholesterol.

Orally bioavailable and blood-brain barrier penetrant, selective and potent inhibitor of lanosterol synthase (LSS)

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable