SML1852

8-Aminoguanosine

≥98% (HPLC)

• Sinônimo(s): 2,8-Diamino-inosine, NSC 90390
• Fórmula empírica (Notação de Hill): C₁₀H₁₄N₆O₅
• Número CAS: 3868-32-4
• Peso molecular: 298.26
• Código UNSPSC: 12352200
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• cor: white to brown
• solubilidade: DMSO: 1 mg/mL, clear (warmed)
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: NC1=NC(C2=C(N1)N([C@@H]3O[C@H](CO)[C@@H](O)[C@H]3O)C(N)=N2)=O
• InChI: 1S/C10H14N6O5/c11-9-14-6-3(7(20)15-9)13-10(12)16(6)8-5(19)4(18)2(1-17)21-8/h2,4-5,8,17-19H,1H2,(H2,12,13)(H3,11,14,15,20)
• chave InChI: FNXPTCITVCRFRK-UHFFFAOYSA-N

Descrição

Ações bioquímicas/fisiológicas

8-Aminoguanosine, a guanosine derivative, is an orally available and highly efficacious potassium-sparing diuretic/natriuretic that increased sodium excretion by 26.2-fold and decrease potassium excretion by 69.1%. 8-Aminoguanosine increases glucose excretion by 12.2-fold. Also 8-Aminoguanosine suppressed deoxycorticosterone/salt-induced hypertension.

8-Aminoguanosine is known to stimulate diuresis, natriuresis, glucosuria and antikaliuresis.[1] It is an analog of guanosine, that can block purine nucleoside phosphorylase, in vitro and in intact lymphoid cells.[2] 8-aminoguanosine triphosphate can be used to block GTP (guanosine triphosphate) cyclohydrolase I from human liver and Escherichia coli.[3]

Orally available and highly efficacious potassium-sparing diuretic/natriuretic

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable