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SML0289

Sigma-Aldrich

Bromfenac sodium

≥98% (HPLC)

Sinônimo(s):

2-Amino-3-(4-bromobenzoyl)benzeneacetic acid sodium salt

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About This Item

Fórmula empírica (Notação de Hill):
C15H11BrNNaO3
Número CAS:
91714-93-1
Peso molecular:
356.15
Número MDL:
MFCD03701673
Código UNSPSC:
12352200
ID de substância PubChem:
329825297
NACRES:
NA.77

Ensaio

≥98% (HPLC)

forma

powder

condição de armazenamento

desiccated

cor

faintly yellow to dark yellow

solubilidade

H2O: ≥5 mg/mL

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[Na+].Nc1c(CC([O-])=O)cccc1C(=O)c2ccc(Br)cc2

InChI

1S/C15H12BrNO3.Na/c16-11-6-4-9(5-7-11)15(20)12-3-1-2-10(14(12)17)8-13(18)19;/h1-7H,8,17H2,(H,18,19);/q;+1/p-1

chave InChI

HZFGMQJYAFHESD-UHFFFAOYSA-M

Informações sobre genes

human ... PTGS1(5742) , PTGS2(5743)

Aplicação

Bromfenac sodium has been used:
  • to study its ability to bind to melanin
  • in the synthesis of bromfenac indolinone standard
  • to analyze its permeability in porcine conjunctiva

Ações bioquímicas/fisiológicas

Bromfenac exhibits antipyretic and prostaglandin synthetase inhibiting properties. It has therapeutic properties against the reduction of ocular pain and inflammation in postoperative cataract patients. Bromfenac acts as an effective agent against allergic conjunctivitis. It has the potential to treat acute muscle pain, osteoarthritis, and rheumatoid arthritis.
Bromfenac is a nonsteroidal anti inflammatory drug (NSAID) that inhibits both COX1 and COX2. It is used as an opthalmic analgesic.

Pictogramas

Skull and crossbones
GHS06

Palavra indicadora

Danger

Frases de perigo

H301

Declarações de precaução

P264 - P270 - P301 + P310 - P405 - P501

Classificações de perigo

Acute Tox. 3 Oral

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

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Neal A Sher et al.
Journal of refractive surgery (Thorofare, N.J. : 1995), 25(2), 214-220 (2009-02-27)
To compare the efficacy of two topical nonsteroidal anti-inflammatory drugs with regards to the control of pain, burning, photophobia, foreign body sensation, and epithelial healing rates in patients who underwent photorefractive keratectomy (PRK). Two hundred twelve eyes were randomized to
Ester Carreño et al.
Clinical ophthalmology (Auckland, N.Z.), 6, 637-644 (2012-05-10)
Ophthalmic bromfenac sodium sesquihydrate is a topically applied selective cyclooxygenase (COX)-2 inhibitor. It is similar to amfenac, except for a bromine atom at the C(4) of the benzoyl ring position, which markedly affects its in vitro and in vivo potency
Keith A Warren et al.
Retina (Philadelphia, Pa.), 30(2), 260-266 (2010-02-23)
The purpose of this study was to evaluate the addition of topical nonsteroidal antiinflammatory drugs (NSAIDs) to intravitreal corticosteroid and antivascular endothelial growth factor injections for the treatment of chronic cystoid macular edema. Thirty-nine patients with chronic pseudophakic cystoid macular
Jeffrey S Heier et al.
Retina (Philadelphia, Pa.), 29(9), 1310-1313 (2009-11-26)
To assess vitreous concentrations of nonsteroidal antiinflammatory drugs (NSAIDs) and prostaglandin E(2) in patients treated with NSAIDs before vitrectomy. This was an investigator-masked, randomized, multicenter study. Patients received ketorolac 0.4% 4 times a day, bromfenac 0.09% 2 times a day
Christina Flaxel et al.
Retina (Philadelphia, Pa.), 32(3), 417-423 (2011-08-25)
To evaluate whether bromfenac eyedrops and ranibizumab intravitreal injections would provide added efficacy over ranibizumab alone. This was a single-site, multiinvestigator, prospective, open-label, interventional, Phase II study of patients with new or recurrent exudative/neovascular age-related macular degeneration. Thirty eyes were
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