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SML0057

Sigma-Aldrich

Camostat mesylate

≥98% (HPLC)

Sinônimo(s):

4-[[4-[(Aminoiminomethyl)amino]benzoyl]oxy]benzeneacetic acid 2-(dimethylamino)-2-oxoethyl ester methanesulfonate; FOY 305; FOY-S 980; Foipan mesylate

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About This Item

Fórmula empírica (Notação de Hill):
C20H22N4O5·CH3SO3H
Número CAS:
59721-29-8
Peso molecular:
494.52
Número MDL:
MFCD00941410
Código UNSPSC:
12352203
ID de substância PubChem:
329825123
NACRES:
NA.77

Ensaio

≥98% (HPLC)

forma

powder

cor

white to tan

solubilidade

H2O: ≥24 mg/mL

originador

Novartis

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CS(O)(=O)=O.CN(C)C(=O)COC(=O)Cc1ccc(OC(=O)c2ccc(NC(N)=N)cc2)cc1

InChI

1S/C20H22N4O5.CH4O3S/c1-24(2)17(25)12-28-18(26)11-13-3-9-16(10-4-13)29-19(27)14-5-7-15(8-6-14)23-20(21)22;1-5(2,3)4/h3-10H,11-12H2,1-2H3,(H4,21,22,23);1H3,(H,2,3,4)

chave InChI

FSEKIHNIDBATFG-UHFFFAOYSA-N

Aplicação

Camostat mesylate has been used to determine the effect of transmembrane protease, serine (TMPRSS) family proteases on cell-cell fusion.
Camostat mesylate may be used in cell signaling studies.

Ações bioquímicas/fisiológicas

Camostat is a synthetic, orally bioavailble serine protease inhibitor and airway epithelial sodium channel (ENaC) attenuator.
Camostat mesylate (CM) is used to treat pancreatitis and reflux esophagitis after gastrectomy.
Camostat mesylate inhibits the production of TNF-α and monocyte chemoattractant protein-1 (MCP-1) by monocytes. It also inhibits the activity of pancreatic stellate cells. Camostat mesylate regulates the cytokine expression and inflammation and is effective in the treatment of dibutyltin dichloride-induced rat pancreatic fibrosis.

Características e benefícios

This compound is featured on the Acid-Sensing (Proton-gated) Ion Channels (ASICs) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictogramas

Exclamation markEnvironment
GHS07,GHS09

Palavra indicadora

Warning

Frases de perigo

H315,H319,H335,H400

Classificações de perigo

Aquatic Acute 1 - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Phenamil methanesulfonate salt solid

Sigma-Aldrich

P203

Phenamil methanesulfonate salt

Ciclesonide European Pharmacopoeia (EP) Reference Standard

Y0001553

Ciclesonide

Yushun Wan et al.
Journal of virology, 94(5) (2019-12-13)
Antibody-dependent enhancement (ADE) of viral entry has been a major concern for epidemiology, vaccine development, and antibody-based drug therapy. However, the molecular mechanism behind ADE is still elusive. Coronavirus spike protein mediates viral entry into cells by first binding to
Hannah Kleine-Weber et al.
Journal of virology, 93(2) (2018-11-09)
Middle East respiratory syndrome coronavirus (MERS-CoV) poses a threat to public health. The virus is endemic in the Middle East but can be transmitted to other countries by travel activity. The introduction of MERS-CoV into the Republic of Korea by
Neurovirulent murine coronavirus JHM. SD uses cellular zinc metalloproteases for virus entry and cell-cell fusion
Phillips J M, et al.
Journal of Virology, JVI-01564 (2017)
Jie Hu et al.
Genes & diseases, 7(4), 551-557 (2020-08-25)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative virus of the coronavirus disease 2019 (COVID-19) pandemic. To establish a safe and convenient assay system for studying entry inhibitors and neutralizing antibodies against SARS-CoV-2, we constructed a codon-optimized, full-length
Junya Gibo et al.
Laboratory investigation; a journal of technical methods and pathology, 85(1), 75-89 (2004-11-09)
Camostat mesilate (CM), an oral protease inhibitor, has been used clinically for the treatment of chronic pancreatitis in Japan. However, the mechanism by which it operates has not been fully understood. Our aim was to evaluate the therapeutic efficacy of
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