Pular para o conteúdo
Merck
Todas as fotos(1)

Documentos Principais

SAB4700518

Sigma-Aldrich

Monoclonal Anti-CD71-FITC antibody produced in mouse

clone MEM-75, purified immunoglobulin, buffered aqueous solution

Sinônimo(s):

Anti-TFRC, Anti-Transferrin Receptor

Faça loginpara ver os preços organizacionais e de contrato

Selecione um tamanho

100 TEST
R$ 2.810,00

R$ 2.810,00


Previsão de entrega em08 de maio de 2025



Selecione um tamanho

Alterar visualização
100 TEST
R$ 2.810,00

About This Item

Código UNSPSC:
12352203
NACRES:
NA.41

R$ 2.810,00


Previsão de entrega em08 de maio de 2025


fonte biológica

mouse

Nível de qualidade

conjugado

FITC conjugate

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

MEM-75, monoclonal

Formulário

buffered aqueous solution

reatividade de espécies

human

técnica(s)

flow cytometry: suitable

Isotipo

IgG1

nº de adesão NCBI

nº de adesão UniProt

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... TFRC(7037)

Descrição geral

Transferrin receptor (TFRC, p90) is also known as cluster of differentiation 71 (CD71). The antibody MEM-75 reacts with CD71 antigen (transferrin receptor), a 95 kDa type II homodimeric transmembrane glycoprotein expressed on activated B and T lymphocytes, macrophages and erythroid precursors; it is lost on resting blood leukocytes. In human chromosome, the gene TFRC is localized on 3q29.

Imunogênio

NALM-6 human pre-B cell line

Aplicação

The reagent is designed for Flow Cytometry analysis of human blood cells using 20 μL reagent / 100 μL of whole blood or 1e6 cells in a suspension. The content of a vial (2 mL) is sufficient for 100 tests.

Ações bioquímicas/fisiológicas

Transferrin receptor (TFRC, CD71) facilitates the uptake of iron bound to transferrin (Tf) through clathrin-mediated endocytosis. TFRC interacts with iron-bound holo-transferrin at pH 7.4 and does not interact apo-transferrin. TFRC also binds with H-ferritin. Expression level of TFRC is regulated stringently by intracellular iron levels. The expression is higher in erythroblasts owing to haemoglobin synthesis. The expression is also higher in cancer cells, osteoclasts and activated lymphocytes, where iron requirement is high. Hypoxia and iron deficiency also increases TFRC expression. Recycling of Tf and TFRC is essential for the uptake of iron from the serum. Mutations in the internalization motif of TFRC leads to impaired endocytosis and consequently congenital/combined immunodeficiency. Improper palmitoylation of TFRC is connected to neurodegeneration with brain iron accumulation. Upregulation of TFRC is implicated in progression of pancreatic cancer, adult T-cell leukemia/lymphoma (ATLL), and cholangiocarcinoma.

Características e benefícios

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

forma física

Solution in phosphate buffered saline containing 15 mM sodium azide and 0.2% high-grade protease free BSA as a stabilizing agent.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Não está encontrando o produto certo?  

Experimente o nosso Ferramenta de seleção de produtos.

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number

Não está vendo a versão correta?

Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

A missense mutation in TFRC, encoding transferrin receptor 1, causes combined immunodeficiency
Jabara HF, et al.
Nature Genetics, 48(1), 74-74 (2016)
Upregulation of transferrin receptor-1 induces cholangiocarcinoma progression via induction of labile iron pool
Jamnongkan W, et al.
Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine, 39(7), 1-10 (2017)
NotI linking/jumping clones of human chromosome 3: mapping of the TFRC, RAB7 and HAUSP genes to regions rearranged in leukaemia and deleted in solid tumours
Kashuba VI, et al.
Febs Letters, 419(2-3), 181-185 (1997)
Impaired transferrin receptor palmitoylation and recycling in neurodegeneration with brain iron accumulation
Drecourt A, et al.
American Journal of Human Genetics, 102(2), 266-277 (2018)
Transferrin receptor regulates pancreatic cancer growth by modulating mitochondrial respiration and ROS generation
Jeong SM, et al.
Biochemical and Biophysical Research Communications, 471(3), 373-379 (2016)

Questions

Reviews

No rating value

Active Filters

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica