SAB4200182

Anti-Glutathione Reductase antibody, Mouse monoclonal

clone GR6, purified from hybridoma cell culture

• Sinônimo(s): Anti-GR, Anti-GSR, Anti-Glutathione-disulfide reductase, Anti-NADPH:oxidized glutathione oxidoreductase
• Número MDL: MFCD01323367
• Código UNSPSC: 12352203
• NACRES: NA.41

Propriedades

• fonte biológica: mouse
• conjugado: unconjugated
• forma do anticorpo: purified from hybridoma cell culture
• tipo de produto de anticorpo: primary antibodies
• clone: GR6, monoclonal
• forma: buffered aqueous solution
• peso molecular: antigen ~55 kDa
• reatividade de espécies: human
• concentração: ~1.0 mg/mL
• técnica(s): immunoprecipitation (IP): suitable; western blot: 2-4 μg/mL using whole extracts of human HepG2 cells.
• Isotipo: IgG1
• nº de adesão UniProt: P00390
• Condições de expedição: dry ice
• temperatura de armazenamento: −20°C
• modificação pós-traducional do alvo: unmodified
• Informações sobre genes: human ... GSR(2936)

Descrição

Descrição geral

Monoclonal Anti-Glutathione Reductase (mouse IgG1 isotype) is derived from the hybridoma GR6 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a human Glutathione reductase recombinant protein. Glutathione reductase is a homodimeric enzyme containing one FAD molecule and NADPH binding domain per subunit. This gene is located on human chromosome 8p.

Imunogênio

mice immunized with a human Glutathione reductase recombinant protein. The corresponding proteins in rat and mouse share 86% and 85% homology, respectively.

Aplicação

Monoclonal Anti-Glutathione Reductase antibody produced in mouse has been used in:

• immunohistochemical
• immunofluorescence studies
• immunoblotting
• immunoprecipitation

Ações bioquímicas/fisiológicas

Glutathione reductase (GR) is a ubiquitous flavoenzyme involved in protecting cells from stress. GR catalyses the reduction of oxidized glutathione (GSSG) to glutathione (GSH). It is an essential component of the glutathione redox cycle, which maintains adequate levels of reduced cellular GSH. GSH serves as an antioxidant and also as an electron donor for glutathione peroxidases and a substrate for glutathione-S-transferases.

forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informações de segurança

• Código de classe de armazenamento: 10 - Combustible liquids
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable