During the B-cell development, IgM (immunoglobulin M) is the first expressed antibody. It is present as a monomer on the surface of naive B cells. Antigenic stimulation and upon maturation, the monomeric IgM units (190kDa), are linked by disulfide bonds to form a pentameric immunoglobulin structure. It also but rarely forms a hexameric structure. The pentameric IgM is linked by a disulfide bond, a polypeptide chain and a J-chain. The μ -chain consists of five domains- VH, Cμ1, Cμ2, Cμ3 and Cμ4.
Especificidade
This product was prepared from monospecific antiserum by a delipidation and defibrination. Assay by immunoelectrophoresis resulted in a single precipitin arc against Bovine IgM and Bovine Serum. No reaction was observed against Bovine IgG F(ab′)2 or Bovine IgG F(c).
Imunogênio
Bovine IgM mu heavy chain
Ações bioquímicas/fisiológicas
The J-chain of the multimeric IgM (immunoglobulin M) structure is responsible for secretion at the mucosal surfaces. The pentameric form of IgM, has a greater affinity towards antigens (with multiple repeating epitopes) compared to the monomers. IgM pentamer enables better opsonization of antigens for destruction and fixing complement.
propriedades físicas
Antibody format: Antiserum
forma física
Supplied in 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Reconstituição
Reconstitute with 1.0 mL deionized water (or equivalent).
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Serum Immunoglobulin M Concentration Is Positively Related to Metabolic Syndrome in an Adult Population: Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) Cohort Study
Kun Song
PLoS ONE, 9(2), e88701-e88701 (2014)
Structure and function of immunoglobulins.
Schroeder Jr H W and Cavacini L
The Journal of Allergy and Clinical Immunology, 125(2), S41-S52 (2010)
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