Pular para o conteúdo
Merck
Todas as fotos(1)

Documentos Principais

Visualizar Toda a Documentação

S4944

Sigma-Aldrich

Monoclonal Anti-Sonic Hedgehog (N-terminal) antibody produced in rat

clone 171018, purified immunoglobulin, lyophilized powder

Sinônimo(s):

Anti-Shh

Faça loginpara ver os preços organizacionais e de contrato

Selecione um tamanho

500 μG
R$ 6.934,00

R$ 6.934,00

Check Cart for Availability
Todas as fotos(1)

Selecione um tamanho

Alterar visualização
500 μG
R$ 6.934,00

About This Item

Número MDL:
MFCD06798717
Código UNSPSC:
51111800
NACRES:
NA.41

R$ 6.934,00

Check Cart for Availability

fonte biológica

rat

Nível de qualidade

100

conjugado

unconjugated

forma do anticorpo

purified immunoglobulin

tipo de produto de anticorpo

primary antibodies

clone

171018, monoclonal

Formulário

lyophilized powder

reatividade de espécies

human, mouse

técnica(s)

capture ELISA: suitable
immunohistochemistry (frozen sections): 25 μg/mL using mouse embryo
neutralization: suitable
western blot: 1-2 μg/test

Isotipo

IgG2a

nº de adesão UniProt

Q15465

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

Informações sobre genes

human ... SHH(6469)
mouse ... Shh(20423)

Categorias relacionadas

Imunogênio

purified, E. coli-derived, recombinant mouse sonic hedgehog N-terminal peptide (amino acids 25-198).

Ações bioquímicas/fisiológicas

Shh protein is secreted by Purkinje cells in the cerebellum with both autocrine and paracrine functions. The Shh signaling is mediated by the interaction of Shh with transmembrane proteins, Patched and Smoothened. The Shh pathway cross-talks Notch and Wnt pathways and acts via downstream targets such as cyclins, gamma catenin, myc and other transcription factors. The Hh family members have multiple roles as morphogens, cell survival factors, setting anterior-posterior axis and digit formation during development of limb and axon guidance factors during the development of brain and nervous system.

forma física

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Não está encontrando o produto certo?  

Experimente o nosso Ferramenta de seleção de produtos.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
MKCD1498
MKCC6415
MKBZ6817V
MKBX9629V
051M1172

Não está vendo a versão correta?

Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.

Pesquise por COA

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Raffaella Bonavita et al.
Biology open, 7(7) (2018-05-23)
In humans, the sacrum forms an important component of the pelvic arch, and it transfers the weight of the body to the lower limbs. The sacrum is formed by collapse of the intervertebral discs (IVDs) between the five sacral vertebrae
Chitra Lekha Dahia et al.
PloS one, 7(4), e35944-e35944 (2012-05-05)
Intervertebral discs (IVD) are essential components of the vertebral column. They maintain separation, and provide shock absorbing buffers, between adjacent vertebrae, while also allowing movements between them. Each IVD consists of a central semi-liquid nucleus pulposus (NP) surrounded by a
Alessia Omenetti et al.
American journal of physiology. Gastrointestinal and liver physiology, 294(3), G595-G598 (2008-01-26)
Hedgehog (Hh) signaling modulates tissue remodeling by controlling the fate of Hh-responsive cells. Healthy adult livers exhibit little Hh activity. However, cells involved in adult liver repair, including myofibroblasts and progenitors, are capable of producing and responding to Hh ligands.
Fergal C Kelleher
Carcinogenesis, 32(4), 445-451 (2010-12-28)
To conduct a systematic review of the role that the hedgehog signaling pathway has in pancreatic cancer tumorigenesis. PubMed search (2000-2010) and literature based references. Firstly, in 2009 a genetic analysis of pancreatic cancers found that a core set of
Shohreh F Farzan et al.
American journal of physiology. Gastrointestinal and liver physiology, 294(4), G844-G849 (2008-02-02)
The Hedgehog (Hh) family of secreted proteins is necessary for aspects of the development and maintenance of the gastrointestinal tract. Hh is thought to function as a morphogen, a mitogen, a cell survival factor, and an axon guidance factor. Given

Artigos

Cancer Stem Cells: Targets for Cancer Therapy

Cancer stem cell media, spheroid plates and cancer stem cell markers to culture and characterize CSC populations.

Questions

Reviews

No rating value

Active Filters

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica