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S0327

Sigma-Aldrich

Scutellarein

≥98% (HPLC)

Sinônimo(s):

4′,5,6,7-Tetrahydroxyflavone, 6-Hydroxyapigenin

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About This Item

Fórmula empírica (Notação de Hill):
C15H10O6
Número CAS:
529-53-3
Peso molecular:
286.24
Número MDL:
MFCD00017692
Código UNSPSC:
12352200
ID de substância PubChem:
329824421
NACRES:
NA.25

fonte biológica

Erigeron breviscapus

Nível de qualidade

100

Ensaio

≥98% (HPLC)

forma

powder

condição de armazenamento

protect from light

cor

yellow

solubilidade

DMSO: 1 mg/mL, clear, greenish-yellow

aplicação(ões)

metabolomics
vitamins, nutraceuticals, and natural products

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

Oc1ccc(cc1)C2=CC(=O)c3c(O)c(O)c(O)cc3O2

InChI

1S/C15H10O6/c16-8-3-1-7(2-4-8)11-5-9(17)13-12(21-11)6-10(18)14(19)15(13)20/h1-6,16,18-20H

chave InChI

JVXZRQGOGOXCEC-UHFFFAOYSA-N

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Ações bioquímicas/fisiológicas

Flavonoid that is selectively cytotoxic toward cancer cells. Induces mitochondrial ROS, DNA damage, and metabolic suppression, preferentially in tumor cells. Scutellarein has been shown to have better absorption than scutellarin in Caco-2 monolayer cells.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Mi-Sun Yu et al.
Bioorganic & medicinal chemistry letters, 22(12), 4049-4054 (2012-05-15)
Severe acute respiratory syndrome (SARS) is an infectious disease with a strong potential for transmission upon close personal contact and is caused by the SARS-coronavirus (CoV). However, there are no natural or synthetic compounds currently available that can inhibit SARS-CoV.
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Journal of pharmaceutical sciences, 100(6), 2452-2459 (2011-01-20)
Antisolvent crystallization can be used as an alternative to cooling or evaporation for the separation and purification of solid product in the pharmaceutical industry. To improve the process understanding of antisolvent crystallization, the use of in-line tools is vital. In
Jian-feng Xing et al.
Acta pharmacologica Sinica, 32(5), 655-663 (2011-04-26)
To study the metabolic and pharmacokinetic profile of scutellarin, an active component from the medical plant Erigeron breviscapus (Vant) Hand-Mazz, and to investigate the mechanisms underlying the low bioavailability of scutellarin though oral or intravenous administration in rats. HPLC method
Xiuhua Hao et al.
Journal of pharmaceutical and biomedical analysis, 38(2), 360-363 (2005-06-01)
A validated HPLC method was developed for the quantification of scutellarin in rat plasma using a liquid-liquid extraction and an ultraviolet detection. Chromatographic separation of scutellarin in plasma was performed on a C18 column, with a mobile phase of acetonitrile-water
Nian-Guang Li et al.
Bioorganic & medicinal chemistry, 20(24), 6919-6923 (2012-11-08)
Two series of 8-aminomethylated derivatives were prepared by Mannich reaction of scutellarein (2) with appropriate aliphatic amines, alicyclic amines and formaldehyde. All the compounds were tested for their thrombin inhibition activity through the analyzation of prothrombin time (PT), activated partial
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