Pular para o conteúdo
Merck
Todas as fotos(2)

Documentos

S0278

Sigma-Aldrich

(±)-Sotalol hydrochloride

≥98% (TLC), powder, β-Adrenoceptor antagonist

Sinônimo(s):

N-[4-[1-Hydroxy-2-(isopropylamino)ethyl]phenyl]methanesulfonamide hydrochloride

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(2)

About This Item

Fórmula empírica (Notação de Hill):
C12H20N2O3S · HCl
Número CAS:
959-24-0
Peso molecular:
308.82
Número CE:
213-496-0
Número MDL:
MFCD00242937
Código UNSPSC:
12352200
ID de substância PubChem:
24278689
NACRES:
NA.77

product name

(±)-Sotalol hydrochloride, ≥98% (TLC), powder

Nível de qualidade

200

Ensaio

≥98% (TLC)

forma

powder

cor

white to off-white

solubilidade

H2O: 20 mg/mL

originador

Bayer

cadeia de caracteres SMILES

Cl.CC(C)NCC(O)c1ccc(NS(C)(=O)=O)cc1

InChI

1S/C12H20N2O3S.ClH/c1-9(2)13-8-12(15)10-4-6-11(7-5-10)14-18(3,16)17;/h4-7,9,12-15H,8H2,1-3H3;1H

chave InChI

VIDRYROWYFWGSY-UHFFFAOYSA-N

Informações sobre genes

human ... ADRB1(153) , ADRB2(154) , ADRB3(155) , KCNH2(3757)

Procurando produtos similares? Visita Guia de comparação de produtos

Aplicação

(±)-Sotalol hydrochloride has been used to test its effect on the cardiac action potential (AP) in human hearts. It has also been used as an β- blocker to determine its effect on free intracellular calcium (Ca2+) release and whole-cell currents in mammalian cancer cells.

Ações bioquímicas/fisiológicas

Potent β-adrenoceptor antagonist; class III antiarrhythmic; prolongs the action potential and increases the refractory period.
Sotalol has a potential to block non-cardioselective β-adrenergic receptors. It acts as an anti-arrhythmic agent and is used as a therapeutic for equine arrhythmias. In addition, sotalol also has an ability to stop atrial fibrillation recurrence.

Características e benefícios

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Bayer. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Os clientes também visualizaram

Slide 1 of 4

1 of 4

N-Acetylprocainamide ≥99%

Sigma-Aldrich

269476

N-Acetylprocainamide

Procainamide hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1252

Procainamide hydrochloride

Bepridil hydrochloride powder

Sigma-Aldrich

B5016

Bepridil hydrochloride

(±)-Propranolol hydrochloride ≥99% (TLC), powder

Sigma-Aldrich

P0884

(±)-Propranolol hydrochloride

A Antony Muthu Prabhu et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 96, 95-107 (2012-06-05)
The inclusion complexation behavior of salbutamol, sotalol and atenolol drugs with β-cyclodextrin (β-CD) were investigated by UV-visible, fluorometry, time resolved fluorescence, FT-IR, (1)H NMR, SEM and PM3 methods. The above drugs gave a single emission maximum in water where as
Mathias Baumert et al.
PloS one, 7(7), e41920-e41920 (2012-08-04)
Increased beat-to-beat variability in the QT interval (QTV) of ECG has been associated with increased risk for sudden cardiac death, but its measurement is technically challenging and currently not standardized. The aim of this study was to investigate the performance
Wei Liu et al.
Pharmaceutical research, 29(7), 1768-1774 (2012-02-22)
To clarify sotalol's classification in the BCS versus BDDCS systems through cellular, rat everted sac and PAMPA permeability studies. Studies were carried out in Madin Darby canine kidney (MDCK) and MDR1-transfected MDCK (MDCK-MDR1) cell lines, rat everted gut sacs and
Amee Shah et al.
The American journal of cardiology, 109(11), 1614-1618 (2012-03-27)
Fetal supraventricular tachycardia (SVT) and atrial flutter (AF) can be associated with significant morbidity and mortality. Digoxin is often used as first-line therapy but can be ineffective and is poorly transferred to the fetus in the presence of fetal hydrops.
Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines
Reyes-Corral M, et al.
Journal of Pharmacology and Experimental Therapeutics, 369(1), 152-162 (2019)
Exibir todos os documentos relacionados

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica