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P5864

Sigma-Aldrich

Proteoglycan from bovine nasal septum

chromatographically purified

Sinônimo(s):

Bovine Proteoglycan, Nasal Proteoglycan

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About This Item

Número MDL:
MFCD00212609
Código UNSPSC:
12352202
NACRES:
NA.61

fonte biológica

bovine nasal septum

Nível de qualidade

100

forma

powder

técnica(s)

cell culture | stem cell: suitable

nº de adesão UniProt

F1MDS0

temperatura de armazenamento

−20°C

Informações sobre genes

bovine ... PRG4(280867)

Descrição geral

Proteoglycans are made up of a core protein to which glycosaminoglycan chains are linked covalently. They are present in many organs, and tissues and found abundantly in the vertebrate cartilage matrix. Proteoglycans are located in the extracellular and pericellular matrix of many cells.

Aplicação

Proteoglycan from bovine nasal septum contains 86% chondroitin sulfate and so has been used to study the effects of chondroitin sulfate proteoglycan in vitro. It has been shown to promote survival of neural stem cells in culture.
Proteoglycan from bovine nasal septum has been used in the induction of arthritis in mice.

Ações bioquímicas/fisiológicas

Proteoglycans are involved in tissue organization and promote cell growth and specialized tissue maturation. They act as biological filters and regulate collagen fibrillogenesis, skin tensile strength, and neurite growth. Proteoglycans are also involved in modulating growth-factor activities, affecting tumor cell growth and invasion, and promoting corneal transparency.

Nota de preparo

Chromatographically purified using 7M urea on DEAE-cellulose by modified procedure by Antonopoulos.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Muly Tham et al.
PloS one, 5(12), e15341-e15341 (2010-12-24)
Understanding how autocrine/paracrine factors regulate neural stem cell (NSC) survival and growth is fundamental to the utilization of these cells for therapeutic applications and as cellular models for the brain. In vitro, NSCs can be propagated along with neural progenitors
Antonopoulos, C.A.
Biochimica et Biophysica Acta, 338, 108-119 (1974)
M Kopec et al.
Scientific reports, 9(1), 166-166 (2019-01-19)
We have shown that Raman microspectroscopy is a powerful method for visualization of glycocalyx offering cellular interrogation without staining, unprecedented spatial and spectral resolution, and biochemical information. We showed for the first time that Raman imaging can be used to

Artigos

Glycosaminoglycans and Proteoglycans

Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.

Glycosaminoglycan Sulfation and Signaling

Glycosaminoglycans are large linear polysaccharides constructed of repeating disaccharide units.

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