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P4306

Sigma-Aldrich

Platelet-Derived Growth Factor-BB human

PDGF-BB, recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinônimo(s):

PDGF-BB

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About This Item

Número MDL:
MFCD00213023
Código UNSPSC:
12352202
NACRES:
NA.77

fonte biológica

human

Nível de qualidade

200

recombinante

expressed in E. coli

Ensaio

≥97% (SDS-PAGE)

forma

lyophilized powder

potência

1.0-3.0 ng/mL EC50

qualidade

endotoxin tested

peso molecular

24.3 kDa

embalagem

pkg of 10 μg

condição de armazenamento

avoid repeated freeze/thaw cycles

técnica(s)

cell culture | mammalian: suitable

Impurezas

≤1 EU/μg

nº de adesão UniProt

P01127

temperatura de armazenamento

−20°C

Informações sobre genes

human ... PDGFB(5155)

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Categorias relacionadas

Descrição geral

Platelet-Derived Growth Factor (PDGF), a cationic polypeptide, is an important serum mitogen predominantly found in cells of mesenchymal origin. PDGF is mapped to human chromosome 7p22.3 and is expressed in smooth muscle cells, endothelial cells and macrophages. PDGF exists as hetero and homodimers : PDGF-AB FDGF-AA, PDGF-BB, PDGF-CC and PDGF-DD.

Aplicação

Platelet-Derived Growth Factor-BB human has been used in induction of DNA synthesis and proliferation in low-concentration serum.

Ações bioquímicas/fisiológicas

Platelet-derived growth factor (PDGF) is a potent chemoattractant and activator of neutrophils, monocytes, and fibroblasts. PDGF elicits multifunctional actions in a variety of cells. It is mitogenic to mesoderm-derived cells, such as dermal and tendon fibroblasts, vascular smooth muscle cells, glial cells and chondrocytes. PDGF-BB isomer is highly expressed in tumor, mediating oncogenic pericyte recruitment and is is a key regulator of angiogenesis. PDGF-BB controls bone homeostasis, repair and regeneration. It increases the synthesis of phospholipids, cholesterol esters, glycogen and prostaglandins and modulates LDL receptor binding.

Outras notas

Dimer of the B chain of human PDGF.

forma física

Lyophilized from a 0.2 μm filtered solution.

Nota de análise

The biological activity is measured by the dose-dependent stimulation of thymidine uptake in BALB/c 3T3 cells.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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The platelet derived growth factor-B polymorphism is associated with risk of severe fever with thrombocytopenia syndrome in Chinese individuals
Zhang XA, et al.
Oncotarget, 7(22), 33340-33349 (2016)
A review of the effects of insulin-like growth factor and platelet derived growth factor on in vivo cartilage healing and repair.
Schmidt MB, et al.
Osteoarthritis and Cartilage / OARS, Osteoarthritis Research Society, 14.5, 403-412 (2006)
Overexpression of platelet-derived growth factor-BB increases tumor pericyte content via stromal-derived factor-1a/CXCR4 axis
Song N, et al.
Cancer Research, 69.15, 6057-6064 (2009)
Growth factors in the treatment of early osteoarthritis
Civinini R, et al.
Clinical Cases in Mineral and Bone Metabolism : The Official Journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases, 10.1, 26-26 (2013)
The role of growth factors in wound healing
David L, et al.
The Surgical Clinics of North America, 77.3, 575-586 (1997)
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Artigos

Platelet Derived Growth Factors (PDGF)

Platelet-Derived Growth Factor is the principal mitogen found in mammalian serum and is released from platelets during clot formation.

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