P2795

Phytosphingosine hydrochloride

• Sinônimo(s): 4-Hydroxysphinganine, D-Ribo-1,3,4-trihydroxy-2-aminooctadecane, D-Ribo-2-aminooctadecane-1,3,4-triol, PHS
• Fórmula empírica (Notação de Hill): C₁₈H₃₉NO₃ · HCl
• Número CAS: 554-62-1
• Peso molecular: 353.97
• Número MDL: MFCD06804643
• Código UNSPSC: 12352211
• ID de substância PubChem: 24898363
• NACRES: NA.25

Propriedades

• forma: powder
• Nível de qualidade: 200
• pontuação do produto alternativo mais ecológico: old score: 19; new score: 9; Find out more about DOZN™ Scoring
• características do produto alternativo mais ecológico: Less Hazardous Chemical Syntheses; Safer Solvents and Auxiliaries; Use of Renewable Feedstocks; Learn more about the Principles of Green Chemistry.
• sustainability: Greener Alternative Product
• categoria alternativa mais ecológica: , Re-engineered
• tipo de lipídio: sphingolipids
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: Cl.CCCCCCCCCCCCCC[C@@H](O)[C@@H](O)[C@@H](N)CO
• InChI: 1S/C18H39NO3.ClH/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17(21)18(22)16(19)15-20;/h16-18,20-22H,2-15,19H2,1H3;1H/t16-,17+,18-;/m0./s1
• chave InChI: GDKAAHDFPOWGQE-RXQQAGQTSA-N

Descrição

Ações bioquímicas/fisiológicas

Phytosphingosine is a long chain sphingoid base that occurs broadly in yeast, plants and animals including mammals. In yeast it is involved in mediating the heat stress response, perhaps through activation of the AGC-type protein kinases, Pkh1, Pkh2, Ypk1, Ypk2, and Sch9. It is proapoptotic in human cancer cell lines. PHS induces ΔΨ_m and release of cytochrome c from mitochondria either directly or through activation of p38 MAPK pathway. This leads to activation of caspase 9 followed by activation of caspase 3 and programmed cell death.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 2
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)