N7764

Nicotinic acid mononucleotide

• Sinônimo(s): Nicotinate mononucleotide
• Fórmula empírica (Notação de Hill): C₁₁H₁₄NO₉P
• Número CAS: 321-02-8
• Peso molecular: 335.20
• Número MDL: MFCD00070358
• Código UNSPSC: 12352106
• ID de substância PubChem: 24897839
• NACRES: NA.79

Propriedades

• fonte biológica: animal
• Nível de qualidade: 200
• Ensaio: ≥98.0% (HPLC)
• Formulário: powder
• técnica(s): HPLC: suitable
• cor: white
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: OC1C(O)C(OC1COP(O)(O)=O)[N]2=CC(=CC=C2)C(O)=O
• InChI: 1S/C11H15NO9P/c13-8-7(5-20-22(17,18)19)21-10(9(8)14)12-3-1-2-6(4-12)11(15)16/h1-4,7-10,13-14H,5H2,(H,15,16)(H2,17,18,19)
• chave InChI: IUJWGLOJJKFASX-UHFFFAOYSA-N

Descrição

Descrição geral

Nicotinic acid mononucleotide (NaMN) is formed from nicotinic acid 5-phosphoribosyl-1-pyrophosphate (PRPP) in the Preiss-Handler pathway in the presence of enzyme phosphoribosyltransferase (NaPRT).[1]

Aplicação

Nicotinic acid mononucleotide has been used as a substrate for NMN/NaMN adenylyltransferase (NMNAT) during nicotinamide adenine dinucleotide (NAD) biosynthesis.[2]

Ações bioquímicas/fisiológicas

Nicotinic acid mononucleotide (NaMN) may be used to study the relationship between the phosphate-responsive signaling (PHO) pathway and nicotine adenine dinucleotide (NAD(+)) metabolism in yeast.[3] Nicotinate mononucleotide is a substrate for NMN/NaMN adenylyltransferase (NMNAT)[4] and nicotinate mononucleotide adenylyltransferase.[5] NaMN amidation results in the synthesis of nicotinamide mononucleotide(NMN), which is further converted to NAD cofactor.[6]

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)