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M5005

Sigma-Aldrich

Manganese(II) chloride tetrahydrate

BioReagent, suitable for insect cell culture

Sinônimo(s):

Manganese chloride hydrate, Manganese chloride tetrahydrate, MnCl2.4H2O

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About This Item

Fórmula linear:
MnCl2 · 4H2O
Número CAS:
13446-34-9
Peso molecular:
197.91
Número CE:
231-869-6
Número MDL:
MFCD00149792
Código UNSPSC:
12352207
ID de substância PubChem:
24896966
NACRES:
NA.28

linha de produto

BioReagent

Nível de qualidade

200

Ensaio

≥99% (by AgNO3, titration)

técnica(s)

cell culture | insect: suitable

pf

58 °C (lit.)

cadeia de caracteres SMILES

Cl[Mn]Cl.[H]O[H].[H]O[H].[H]O[H].[H]O[H]

InChI

1S/2ClH.Mn.4H2O/h2*1H;;4*1H2/q;;+2;;;;/p-2

chave InChI

CNFDGXZLMLFIJV-UHFFFAOYSA-L

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Aplicação

Manganese(II) chloride tetrahydrate has been used:
  • as trace element in the fungal complete medium
  • as a supplement in the culture medium for cochlear organotypic culture
  • to determine its in vivo antiviral activity against herpes simplex virus-1 (HSV-1), vesicular stomatitis virus (VSV) and vaccinia virus in mice

Ações bioquímicas/fisiológicas

Manganese is an essential and one of the abundant metal in the tissues of mammals. It plays a key role in the physiological process like development, neuronal function, immune regulation, reproduction, and antioxidant defences. It functions as a cofactor and regulates the activity of the enzymes like oxido-reductases, isomerases, transferases, ligases, lyases and hydrolases It is involved in the innate immunity against viruses.

Palavra indicadora

Danger

Frases de perigo

H301,H318,H373

Classificações de perigo

Acute Tox. 3 Oral - Eye Dam. 1 - STOT RE 2

Órgãos-alvo

Brain

Código de classe de armazenamento

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

does not flash

Ponto de fulgor (°C)

does not flash

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Salidroside protects inner ear hair cells and spiral ganglion neurons from manganese exposure by regulating ROS levels and inhibiting Apoptosis
Ding X, et al.
Toxicology Letters, 310, 51-60 (2019)
manganese Increases the Sensitivity of the cgas-sting Pathway for Double-stranded Dna and Is Required for the Host Defense against Dna Viruses.
Wang C, et al.
Immunity, 48(4), 675-687 (2018)
Weilong Wang et al.
Toxicology letters, 279, 77-86 (2017-08-06)
Manganese (Mn) is an indispensable cofactor for many enzymes and a basic factor for many reproductive and metabolic pathways. However, exposure to high concentrations of Mn can result in deleterious effects on the central nervous system and peripheral nerves, including
Xuerui Ding et al.
Toxicology letters, 310, 51-60 (2019-04-17)
Manganese (Mn) is an essential cofactor for many enzymes and thus plays an important role in normal growth and development. However, persistent exposure to high Mn concentrations can result in deleterious effects on not only the central nervous system but
Agrobacterium-mediated transformation of the filamentous fungus Aspergillus awamori.
Michielse CB, et al.
Nature Protocols, 3(10), 1671-1671 (2008)
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