M4537
Mycolic acid from Mycobacterium tuberculosis (bovine strain)
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About This Item
Produtos recomendados
fonte biológica
Mycobacterium tuberculosis (bovine strain)
descrição
mixture of homologous acids
Formulário
powder
grupo funcional
carboxylic acid
tipo de lipídio
unsaturated FAs
temperatura de armazenamento
−20°C
Ações bioquímicas/fisiológicas
Mycolic acids are long chain fatty acid containing molecules found in the cell walls of mycolata taxon bacteria. Mycolic acid from Mycobacterium tuberculosis (bovine strain) may be used to study mechanisms of resistance to antibiotic drug treatment and the toxicity of tuberculosis bacteria.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Guanghou Shui et al.
EMBO molecular medicine, 4(1), 27-37 (2011-12-08)
Mycolic acids are attractive diagnostic markers for tuberculosis (TB) infection because they are bacteria-derived, contain information about bacterial species, modulate host-pathogen interactions and are chemically inert. Here, we present a novel approach based on mass spectrometry. Quantification of specific precursor
Anna E Grzegorzewicz et al.
Nature chemical biology, 8(4), 334-341 (2012-02-22)
New chemotherapeutics active against multidrug-resistant Mycobacterium tuberculosis are urgently needed. We report on the identification of an adamantyl urea compound that shows potent bactericidal activity against M. tuberculosis and a unique mode of action, namely the abolition of the translocation
Damien J Montamat-Sicotte et al.
The Journal of clinical investigation, 121(6), 2493-2503 (2011-05-18)
Current tuberculosis (TB) vaccine strategies are largely aimed at activating conventional T cell responses to mycobacterial protein antigens. However, the lipid-rich cell wall of Mycobacterium tuberculosis (M. tuberculosis) is essential for pathogenicity and provides targets for unconventional T cell recognition.
Kapil Tahlan et al.
Antimicrobial agents and chemotherapy, 56(4), 1797-1809 (2012-01-19)
SQ109, a 1,2-diamine related to ethambutol, is currently in clinical trials for the treatment of tuberculosis, but its mode of action remains unclear. Here, we demonstrate that SQ109 disrupts cell wall assembly, as evidenced by macromolecular incorporation assays and ultrastructural
Mervyn Beukes et al.
Chemistry and physics of lipids, 163(8), 800-808 (2010-09-30)
Cell wall mycolic acids (MA) from Mycobacterium tuberculosis (M.tb) are CD1b presented antigens that can be used to detect antibodies as surrogate markers of active TB, even in HIV coinfected patients. The use of the complex mixtures of natural MA
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