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Documentos Principais

M4280

Sigma-Aldrich

Anti-Mouse IgG (Fc specific) antibody produced in goat

2.0 mg/mL, affinity isolated antibody

Sinônimo(s):

Anti Mouse Fc Antibody, Anti Mouse Fc Antibody - Anti-Mouse IgG (Fc specific) antibody produced in goat

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1 ML
R$ 1.611,00

R$ 1.611,00


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1 ML
R$ 1.611,00

About This Item

Número MDL:
Código UNSPSC:
12352203
NACRES:
NA.46

R$ 1.611,00


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fonte biológica

goat

conjugado

unconjugated

forma do anticorpo

affinity isolated antibody

tipo de produto de anticorpo

secondary antibodies

clone

polyclonal

concentração

2.0 mg/mL

técnica(s)

indirect ELISA: 1:20,000

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

modificação pós-traducional do alvo

unmodified

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Descrição geral

Immunoglobulin G (IgG) belongs to the immunoglobulin family and is a widely expressed serum antibody. Immunoglobulins have two heavy chains and two light chains connected by a disulfide bond. It mainly helps in immune defense. It is a glycoprotein. IgG is a major class of immunoglobulin. Mouse consists of five immunoglobulin classes- IgM, IgG, IgA, IgD and IgE. Mouse IgG is further divided into five classes- IgG1, IgG2a, IgG2b and IgG3. IgG helps in opsonization, complement fixation and antibody dependent cell mediated cytotoxicity.

Imunogênio

Fc fragment of IgG purified from mouse.

Aplicação

Anti-Mouse IgG (Fc specific) antibody produced in goat has been used in:
  • enzyme-linked immunosorbent assay (ELISA)
  • flow cytometry
  • immunoprecipitation
  • immunoblotting

Ações bioquímicas/fisiológicas

IgG antibody plays a crucial role in humoral immune responses such as complement activation, phagocytosis, placental transport and cell surface-receptor binding. The antigen binding activity is mediated by the variable Fab region of IgG antibodies, whereas the effector activities are stimulated by the Fc domain. Anti-mouse IgG (Fc specific) antibody can be used to detect the optimal capture agents.
Immunoglobulin G (IgG) participates in hypersensitivity type II and type III reactions. It mainly helps in immune defense. IgG helps in opsonization, complement fixation and antibody dependent cell mediated cytotoxicity.

Outras notas

Antibody adsorbed with bovine, equine and human serum proteins.

forma física

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Nota de preparo

Adsorbed to reduce background staining with bovine, horse or human samples.

Exoneração de responsabilidade

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

nwg

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable


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T Groot Kormelink et al.
Allergy, 67(9), 1165-1172 (2012-07-07)
Free light chain (FLC) concentrations are demonstrated to be increased in different inflammatory disorders and are proposed to mediate mast cell-dependent immune responses. A role for mast cells is suggested in chronic rhinosinusitis with nasal polyposis (CRSwNP), which is characterized
Esmaeil Mortaz et al.
Journal of inflammation (London, England), 12, 21-21 (2015-04-14)
Sarcoidosis is a systemic disease of unknown etiology characterized histologically by the observation of non-caseating granulomas and several immunological abnormalities. Sarcoidosis is a multi-organ disorder which involves formation of granulomas in many tissues including the lungs (pulmonary) and others such
Oded Nahshol et al.
Analytical biochemistry, 383(1), 52-60 (2008-09-11)
The production of antibodies for diagnostic and therapeutic applications is a major focus for biotechnology and pharmaceutical companies, and it requires the development of fast, high-throughput methodologies for screening and selecting appropriate candidate antibodies for development. These candidates must have
Lina Y Dimberg et al.
Molecular cancer research : MCR, 15(4), 382-394 (2017-01-22)
TRAIL is a potent death-inducing ligand that mediates apoptosis through the extrinsic pathway and serves as an important endogenous tumor suppressor mechanism. Because tumor cells are often killed by TRAIL and normal cells are not, drugs that activate the TRAIL
A genome-wide loss-of-function screen identifies SLC26A2 as a novel mediator of TRAIL resistance
Dimberg LY, et al.
Molecular Cancer Research, 15(4), 382-394 (2017)

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