M2420
Monoclonal Anti-Monocyte Chemotactic Protein-1 antibody produced in mouse
clone 24822, purified immunoglobulin, lyophilized powder
Sinônimo(s):
Anti-CCL2, Anti-MCP-1
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About This Item
Produtos recomendados
fonte biológica
mouse
Nível de qualidade
conjugado
unconjugated
forma do anticorpo
purified immunoglobulin
tipo de produto de anticorpo
primary antibodies
clone
24822, monoclonal
forma
lyophilized powder
reatividade de espécies
human
técnica(s)
neutralization: suitable
western blot: suitable
Isotipo
IgG1
nº de adesão UniProt
temperatura de armazenamento
−20°C
modificação pós-traducional do alvo
unmodified
Informações sobre genes
human ... CCL2(6347)
Descrição geral
Monocyte Chemotactic Protein-1 (MCP-1) is a chemotactic factor that belongs to CC chemokine family and can attract basophils and monocytes but not eosinophils or neutrophils. It is produced in keratinocytes, fibroblasts, hepatoma cells and Type II pneumocytes in response to IL-1. It has a crucial role in recruiting immune cells to the site of antigens as well as behaves as an inflammatory mediator which stimulates the directional migration of T cells and monocytes. Monoclonal anti-Monocyte Chemotactic Protein-1 antibody is suitable for neutralization, in which it will not neutralize the activity of recombinant human MIP-1α, recombinant mouse MIP-1α or recombinant human RANTES. Mouse anti-Monocyte Chemotactic Protein-1 antibody reacts specifically with human MCP-1/CCL2.
Especificidade
The antibody will neutralize the biological activity of recombinant human MCP-1.This antibody does not exhibit cross-reactivity with recombinant human RANTES, recombinant human MIP-1α, or recombinant mouse MIP-1α..
Imunogênio
recombinant human MCP-1/CCL2 expressed in E. coli.
Aplicação
Monoclonal anti-Monocyte Chemotactic Protein-1 antibody can be used in western blotting.
forma física
Lyophilized from a 0.2 μm solution in phosphate buffered saline containing carbohydrates.
Nota de preparo
Purified using protein A.
Exoneração de responsabilidade
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
Certificados de análise (COA)
Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.
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Haijun Zhang et al.
The journal of pain : official journal of the American Pain Society, 14(10), 1031-1044 (2013-06-04)
The use of paclitaxel (Taxol), a microtubule stabilizer, for cancer treatment is often limited by its associated peripheral neuropathy (chemotherapy-induced peripheral neuropathy [CIPN]), which predominantly results in sensory dysfunction, including chronic pain. Here we show that paclitaxel CIPN was associated
D D Taub et al.
The Journal of clinical investigation, 95(3), 1370-1376 (1995-03-01)
Monocyte chemotactic protein (MCP)-1, -2, and -3 all have been shown to induce monocyte/macrophage migration in vitro and MCP-1, also known as MCAF, chemoattracts basophils and mast cells. We report here that natural MCP-1 as well as synthetic preparations of
Y Furutani et al.
Biochemical and biophysical research communications, 159(1), 249-255 (1989-02-28)
cDNA clones having a nucleotide sequence encoding a human monocyte chemotactic and activating factor (MCAF) were isolated and sequenced. The amino acid sequence deduced from the nucleotide sequence reveals the primary structure of the MCAF precursor to be composed of
Kenichiro Kobayashi et al.
Hepatology communications, 2(3), 230-236 (2018-03-07)
Liver fibrosis is a common complication associated with transient myeloproliferative disorder (TMD) in Down syndrome (DS). The exact molecular pathogenesis that regulates disease progression is largely unknown. We recently found serum and/or urinary monocyte chemoattractant protein-1 (MCP-1) as a novel
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