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M1809

Sigma-Aldrich

MRS 1523

>98% (HPLC)

Sinônimo(s):

3-Propyl-6-ethyl-5-[(ethylthio)carbonyl]-2 phenyl-4-propyl-3-pyridine carboxylate

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About This Item

Fórmula empírica (Notação de Hill):
C23H29NO3S
Número CAS:
212329-37-8
Peso molecular:
399.55
Número MDL:
MFCD03787977
Código UNSPSC:
12352200
ID de substância PubChem:
24278127
NACRES:
NA.77

Nível de qualidade

100

Ensaio

>98% (HPLC)

forma

oil

cor

colorless to light brown

solubilidade

DMSO: >10 mg/mL
H2O: insoluble

Condições de expedição

wet ice

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CCCOC(=O)c1c(CCC)c(C(=O)SCC)c(CC)nc1-c2ccccc2

InChI

1S/C23H29NO3S/c1-5-12-17-19(23(26)28-8-4)18(7-3)24-21(16-13-10-9-11-14-16)20(17)22(25)27-15-6-2/h9-11,13-14H,5-8,12,15H2,1-4H3

chave InChI

UUSHFEVEROROSP-UHFFFAOYSA-N

Informações sobre genes

human ... ADORA3(140)
rat ... Adora1(29290) , Adora2a(25369) , Adora3(25370)

Aplicação

MRS 1523 has been used as an inhibitor of adenosine receptors in SW1990 and BxPC3 pancreatic cancer cells, LX2 human hepatic stellate cells and human coronary smooth muscle cells.

Ações bioquímicas/fisiológicas

MRS 1523 is a selective adenosine A3 receptor antagonist in the rat.

Características e benefícios

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informações legais

Sold under license from the National Institutes of Health

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Suramin sodium salt ≥98% (TLC)

Sigma-Aldrich

S2671

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Lipopolysaccharides from Klebsiella pneumoniae purified by phenol extraction

Sigma-Aldrich

L4268

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Elacridar ≥98% (HPLC)

Sigma-Aldrich

SML0486

Elacridar

MRS Broth suitable for microbiology, NutriSelect® Basic

Millipore

69966

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Adenosine ≥99%

Sigma-Aldrich

A9251

Adenosine

The A3 adenosine receptor agonist, namodenoson, ameliorates non-alcoholic steatohepatitis in mice
Fishman P, et al.
International Journal of Molecular Medicine, 44(6), 2256-2264 (2019)
C H Mitchell et al.
The American journal of physiology, 276(3 Pt 1), C659-C666 (1999-03-10)
Adenosine stimulates Cl- channels of the nonpigmented (NPE) cells of the ciliary epithelium. We sought to identify the specific adenosine receptors mediating this action. Cl- channel activity in immortalized human (HCE) NPE cells was determined by monitoring cell volume in
Shira Cohen et al.
Journal of immunology research, 2018, 2310970-2310970 (2018-06-05)
Interleukin-17 and interleukin-23 play major roles in the inflammatory process in psoriasis. The Gi protein-associated A3 adenosine receptor (A3AR) is known to be overexpressed in inflammatory cells and in peripheral blood mononuclear cells (PBMCs) of patients with autoimmune inflammatory conditions.
Elena Lucarini et al.
Pain, 161(9), 2179-2190 (2020-05-08)
Pharmacological tools for chronic visceral pain management are still limited and inadequate. A3 adenosine receptor (A3AR) agonists are effective in different models of persistent pain. Recently, their activity has been related to the block of N-type voltage-gated Ca2+ channels (Cav2.2)
A H Li et al.
Journal of medicinal chemistry, 41(17), 3186-3201 (1998-08-14)
The structure-activity relationships of 6-phenyl-1,4-dihydropyridine derivatives as selective antagonists at human A3 adenosine receptors have been explored (Jiang et al. J. Med. Chem. 1997, 39, 4667-4675). In the present study, related pyridine derivatives have been synthesized and tested for affinity
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