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M1574

Sigma-Aldrich

Miglitol

Sinônimo(s):

1-(2-Hydroxyethyl)-2-(hydroxymethyl)piperidine-3,4,5-triol

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About This Item

Fórmula empírica (Notação de Hill):
C8H17NO5
Número CAS:
72432-03-2
Peso molecular:
207.22
Número CE:
276-661-6
Código UNSPSC:
12352205
NACRES:
NA.25

fonte biológica

synthetic (organic)

Ensaio

≥98% (HPLC)

forma

powder

pf

142-147  °C

solubilidade

water: 5 mg/mL, clear, colorless to faintly yellow

temperatura de armazenamento

room temp

InChI

1S/C8H17NO5/c10-2-1-9-3-6(12)8(14)7(13)5(9)4-11/h5-8,10-14H,1-4H2/t5-,6+,7-,8-/m1/s1

chave InChI

IBAQFPQHRJAVAV-ULAWRXDQSA-N

Descrição geral

Miglitol is an alpha-glucosidase inhibitor used as a glucose-lowering drug in diabetes research.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Kazuki Mochizuki et al.
Bioscience, biotechnology, and biochemistry, 74(12), 2470-2474 (2010-12-15)
β(2) integrins (CD11s/CD18) promote the attachment of leukocytes to vascular endothelial cells. We performed in this study sucrose loading to rats with moderate postprandial hyperglycemia with/without once-daily dosing of the α-glucosidase inhibitor, miglitol, for 4 days under 4-h fasting conditions.
Kazuki Mochizuki et al.
Metabolism: clinical and experimental, 60(11), 1560-1565 (2011-05-10)
Otsuka Long-Evans Tokushima Fatty (OLETF) rats, an animal model of type 2 diabetes mellitus, exhibit chronic and slowly progressive hyperglycemia with obesity. In this study, we examined whether dietary supplementation with the α-glucosidase inhibitor miglitol from the preonset stage improves
Sheng-Hwu Hsieh et al.
Acta diabetologica, 48(1), 71-77 (2010-10-22)
The objective of this study is to examine the efficacy and tolerability of miglitol with respect to improving glycemic control in Chinese patients with type 2 diabetes mellitus inadequately controlled by diet and sulfonylurea treatment. This was a randomized, double-blinded
Kazutaka Aoki et al.
Acta diabetologica, 49(3), 225-230 (2011-09-08)
We recently reported that the administration of miglitol alone just before breakfast improved postprandial hyperglycemia and increased active glucagon-like peptide-1 (GLP-1) levels after lunch in men without diabetes. Miglitol and dipeptidyl peptidase-4 inhibitors, such as sitagliptin, enhance plasma active GLP-1
Takuo Emoto et al.
The American journal of cardiology, 109(1), 42-46 (2011-09-29)
Repeated postprandial hyperglycemia may play an important role in the development of atherosclerosis by suppressing vascular endothelial function. Although miglitol suppresses the elevation of blood glucose levels shortly after a meal more than other α-glucosidase inhibitors, the effect of 3-month
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