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A8980

Sigma-Aldrich

Acarbose

≥95% (HPLC)

Sinônimo(s):

4”,6”-Didesoxi-4"-([1S]-[1,4,6/5]-4,5,6-tri-hidroxi-3-hidroximetil-2-ciclo-hexenilamino)-maltotriose

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1 G
R$ 2.700,00

R$ 2.700,00

Disponível para enviar em11 de abril de 2025Detalhes

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1 G
R$ 2.700,00

About This Item

Fórmula empírica (Notação de Hill):
C25H43NO18
Número CAS:
56180-94-0
Peso molecular:
645.60
Número CE:
260-030-7
Número MDL:
MFCD00869592
Código UNSPSC:
12352201
ID de substância PubChem:
329771024
NACRES:
NA.25

R$ 2.700,00

Disponível para enviar em11 de abril de 2025Detalhes

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fonte biológica

bacterial (Actinoplanes)

Ensaio

≥95% (HPLC)

Formulário

powder

Impurezas

<9.4% water (Karl Fischer)

cor

white to off-white

solubilidade

H2O (CO2 free): 50 mg/mL, clear, colorless

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

C[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O[C@@H]2CO)O[C@H]3[C@H](O)[C@@H](O)[C@H](O)O[C@@H]3CO)[C@H](O)[C@@H](O)[C@@H]1N[C@H]4C=C(CO)[C@@H](O)[C@H](O)[C@H]4O

InChI

1S/C25H43NO18/c1-6-11(26-8-2-7(3-27)12(30)15(33)13(8)31)14(32)19(37)24(40-6)43-22-10(5-29)42-25(20(38)17(22)35)44-21-9(4-28)41-23(39)18(36)16(21)34/h2,6,8-39H,3-5H2,1H3/t6-,8+,9-,10-,11-,12-,13+,14+,15+,16-,17-,18-,19-,20-,21-,22-,23-,24-,25-/m1/s1

chave InChI

XUFXOAAUWZOOIT-SXARVLRPSA-N

Informações sobre genes

human ... AMY2A(279) , MGAM(8972)

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Categorias relacionadas

Aplicação

Acarbose, a derivitized maltotriose antidiabetic drug, is a reversible α-glucosidase inhibitor used in medical studies to control the effects of Type II diabetes. Acarbose is often used as a reference to which other α-glucosidase inhibitors are compared.

Ações bioquímicas/fisiológicas

Tetrassacarídeo modificado que age como inibidor reversível da α-glucosidase.

Outras notas

To gain a comprehensive understanding of our extensive range of Oligosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 1

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Escolha uma das versões mais recentes:

Certificados de análise (COA)

Lot/Batch Number
0000410797
0000364921
0000410797
WXBF4600V
0000364921

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Ashley S Boath et al.
Food chemistry, 135(3), 929-936 (2012-09-08)
Polyphenol-rich extracts from certain berries inhibited α-glucosidase activity in vitro. The two most effective berry extracts, from black currant and rowanberry, inhibited α-glucosidase with IC(50) values respectively of 20 and 30μg GAE/ml and were as effective as the pharmaceutical inhibitor
Ranee Singh et al.
Journal of feline medicine and surgery, 17(10), 848-857 (2014-10-26)
Feeding a low carbohydrate diet is recommended for diabetic cats; however, some cats may require diets containing moderate-to-high carbohydrate and may benefit from the use of therapeutic agents to improve glycemic control. The aim of the study was to determine
Alessandro Leone et al.
Nutrients, 10(10) (2018-10-17)
The hypoglycemic effect in humans of Moringa oleifera (MO) leaf powder has, to date, been poorly investigated. We assessed the chemical composition of MO leaf powder produced at Saharawi refugee camps, its in vitro ability to inhibit α-amylase activity, and
Muhammad Jihad Sandikapura et al.
Pakistan journal of pharmaceutical sciences, 31(2(Suppl.)), 623-635 (2018-04-08)
The study was aimed to perform aqueous extraction of two plants using different extraction methods, and evaluate their antioxidant and antidiabetic potential. Plant materials were extracted by maceration, soxhlet, sonication and fresh juice methods to produce aqueous extracts. In vitro
Patrick Schwientek et al.
BMC genomics, 13, 112-112 (2012-03-27)
Actinoplanes sp. SE50/110 is known as the wild type producer of the alpha-glucosidase inhibitor acarbose, a potent drug used worldwide in the treatment of type-2 diabetes mellitus. As the incidence of diabetes is rapidly rising worldwide, an ever increasing demand
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Questions

1–3 of 3 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  3. What is the half life of this drug? Can we prepare 10mL and store it for weeks?

    1 answer

    1. Unfortunately, the half life and the solution stability is not determined for this product.

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