L5037
Leptin from rat
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder
Sinônimo(s):
OB
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1 MG
R$ 1.629,00
About This Item
Produtos recomendados
fonte biológica
Escherichia coli
Nível de qualidade
recombinante
expressed in E. coli
esterilidade
non-sterile
Ensaio
≥97% (SDS-PAGE)
Formulário
lyophilized powder
potência
≤0.8 ng/mL ED50
peso molecular
16 kDa
Impurezas
≤1.0 EU/μg endotoxin
nº de adesão UniProt
Condições de expedição
ambient
temperatura de armazenamento
−20°C
Informações sobre genes
rat ... Lep(25608)
Aplicação
Leptin from rat has been used:
- to check the effect of intranasal nerve growth factor (NGF) on NGF activity in the spinal cord of Sprague-Dawley rats[1]
- for validation of labelling for leptin-bearing cells of Sprague-Dawley rats[2]
- to study the effect of leptin on STAT3 (signal transducer and activator of transcription 3) phosphorylation in neural population of Sprague-Dawley rats[3]
- to study leptin response towards chemoreflex in nucleus of the solitary tract[4]
- in rats, to check the effect of association between leptin and neuronal nitric oxide pathway on penicillin-induced epileptiform activity[5]
Ações bioquímicas/fisiológicas
Hormone produced primarily in adipocytes; primary site of action appears to be on neurons in the hypothalamus that are involved in regulating energy balance, appetite, and body weight.
In rodents with uncontrolled diabetes mellitus, leptin is crucial for normalizing hyperglycemia.[6] In the digestive tract, it also participates in the absorption of dietary molecules via controlling transporters activity.[7]
Leptin is a hormone produced primarily in adipocytes, although leptin mRNA has also been identified in placenta and fetal tissues, gastric tissue and liver. Its primary site of action appears to be on neurons in the hypothalamus that are involved in regulating energy balance, appetite, and body weight. Leptin increases the production of nitric oxide in endothelial cells and stimulates angiogenesis in vitro and in vivo.
Human and mouse leptin share ~84% sequence identity.
Human and mouse leptin share ~84% sequence identity.
forma física
Lyophilized from a 0.2 μm filtered solution with 4.5 mM NaHCO3.
Nota de análise
The biological activity is measured by its ability to induce proliferation of leptin-dependent human OB-R transfected murine BAF3 cells.
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 3
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Equipamento de proteção individual
Eyeshields, Gloves, type N95 (US)
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Gregory J Morton et al.
The Journal of clinical investigation, 125(12), 4587-4591 (2015-11-04)
Leptin administration restores euglycemia in rodents with severe insulin-deficient diabetes, and recent studies to explain this phenomenon have focused on the ability of leptin to normalize excessive hypothalamic-pituitary-adrenal (HPA) axis activity. Here, we employed a streptozotocin-induced rat model (STZ-DM) of
Iris A McDuffie et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 52(2), 263-273 (2004-01-20)
Leptin, the ob protein, regulates food intake and satiety and can be found in the anterior pituitary. Leptin antigens and mRNA were studied in the anterior pituitary (AP) cells of male and female rats to learn more about its regulation.
John Ciriello et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 303(7), R727-R736 (2012-08-24)
Circulating levels of leptin are elevated in individuals suffering from chronic intermittent hypoxia (CIH). Systemic and central administration of leptin elicits increases in sympathetic nervous activity (SNA), arterial pressure (AP), and heart rate (HR), and it attenuates the baroreceptor reflex
Carmen Fanjul et al.
Journal of physiology and biochemistry, 71(2), 311-317 (2015-05-04)
Leptin is secreted into the digestive tract and contributes to the absorption of dietary molecules by regulating transporters activity. Here, we studied the effect of luminal leptin on the intestinal transport of L-glutamate, an important component of human diet. We
James W Maniscalco et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 306(8), R576-R585 (2014-02-14)
Leptin released peripherally acts within the central nervous system (CNS) to modulate numerous physiological and behavioral functions. Histochemical identification of leptin-responsive CNS cells can reveal the specific cellular phenotypes and neural circuits through which leptin signaling modulates these functions. Leptin
Artigos
Lipid Induced Insulin Resistance
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