Pular para o conteúdo
Merck
Todas as fotos(2)

Documentos

L4021

Sigma-Aldrich

Prolactin human

recombinant, expressed in E. coli, lyophilized powder, BioReagent, suitable for cell culture, >97% (SDS-PAGE)

Sinônimo(s):

hPRL, LTH, Lactogenic Hormone, Luteotropic Hormone, PRL

Faça loginpara ver os preços organizacionais e de contrato
Todas as fotos(2)

About This Item

Número CAS:
9002-62-4
Número MDL:
MFCD00131553
Código UNSPSC:
51111800
NACRES:
NA.77

recombinante

expressed in E. coli

Nível de qualidade

200

descrição

200 amino acid residue methionyl form of mature, recombinant human prolactin (amino acid residues 29-227).

linha de produto

BioReagent

Ensaio

>97% (SDS-PAGE)

forma

lyophilized powder

potência

0.030-0.300 ng/mL EC50

peso molecular

predicted mol wt ~24 kDa

técnica(s)

cell culture | mammalian: suitable

Impurezas

endotoxin, tested

solubilidade

water: 0.5000 mL, clear, colorless

nº de adesão UniProt

P01236

Condições de expedição

ambient

temperatura de armazenamento

−20°C

Informações sobre genes

human ... PRL(5617)

Categorias relacionadas

Aplicação

Use in cell culture applications to study prolactin regulation of cell signaling and gene expression.

Ações bioquímicas/fisiológicas

Prolactin is a neuroendocrine hormone. The prolactin receptor is a transmembrane glycoprotein that belongs to the cytokine hematopoietic receptor family. A large number of cells and organs express the receptor, including B cells, T cells, macrophages, monocytes, and neutrophils. Prolactin signal transduction involves the JAK/STAT families and the src kinase family. Induces lactation; inhibits secretion of gonadotropins; release is inhibited by dopamine.

Outras notas

Contains an N-terminal methionine not present in the natural product.

forma física

Lyophilized from a solution in 10 mM phosphate and 50 mM sodium chloride, pH 8.0.

Reconstituição

It is recommended that sterile 4 mM HCl containing 1 mg/mL bovine serum albumin be added to the vial to prepare a stock solution of no less than 100 μg/mL.

Nota de análise

The biological activity is assayed by proliferation of the rat lymphoma cell line, Nb2-11.

Pictogramas

Health hazard
GHS08

Palavra indicadora

Danger

Frases de perigo

H360

Declarações de precaução

P201 - P308 + P313

Classificações de perigo

Repr. 1B

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

Já possui este produto?

Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.

Visite a Biblioteca de Documentos

Os clientes também visualizaram

Slide 1 of 1

1 of 1

Hidrocortisona BioReagent, suitable for cell culture

Sigma-Aldrich

H0888

Hidrocortisona

Extrapituitary prolactin: distribution, regulation, functions, and clinical aspects.
N Ben-Jonathan et al.
Endocrine reviews, 17(6), 639-669 (1996-12-01)
G Bellone et al.
Journal of cellular physiology, 163(2), 221-231 (1995-05-01)
The pituitary hormone prolactin (Prl) is known to act as a local regulator of immune cell function, and Prl-binding receptors (Prl-R) have been described to share distinctive features with the members of the newly described cytokine/hemopoietin receptor superfamily. Here we
Julien Auffret et al.
American journal of physiology. Endocrinology and metabolism, 305(10), E1309-E1318 (2013-09-26)
Prolactin (PRL) and placental lactogens stimulate β-cell replication and insulin production in pancreatic islets and insulinoma cells through binding to the PRL receptor (PRLR). However, the contribution of PRLR signaling to β-cell ontogeny and function in perinatal life and the
Bibiana Moreno-Carranza et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 305(7), R720-R726 (2013-08-21)
Prolactin (PRL) is a potent liver mitogen and proangiogenic hormone. Here, we used hyperprolactinemic rats and PRL receptor-null mice (PRLR(-/-)) to study the effect of PRL on liver growth and angiogenesis before and after partial hepatectomy (PH). Liver-to-body weight ratio
Gerda de Kuijper et al.
Research in developmental disabilities, 34(9), 2799-2809 (2013-06-25)
Individuals with intellectual disability frequently use antipsychotics for many years. This may have detrimental health effects, including neurological symptoms and metabolic and hormonal dysregulation, the latter possibly affecting bone metabolism. There is large variability in the degree in which antipsychotic
Exibir todos os documentos relacionados

Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.

Entre em contato com a assistência técnica