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L0401

Sigma-Aldrich

Lectin from Lycopersicon esculentum (tomato)

FITC conjugate, buffered aqueous solution

Sinônimo(s):

Lycopersicon esculentum agglutinin, LEA

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About This Item

Código UNSPSC:
12352202
NACRES:
NA.32

conjugado

FITC conjugate

Nível de qualidade

200

forma

buffered aqueous solution

Extensão da rotulagem

2.0-6.0 mol FITC per mol lectin

temperatura de armazenamento

2-8°C

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Descrição geral

Lectins are carbohydrate binding proteins. Lectin from Lycopersicon esculentum (LEA) binds strongly to polylactosamine oligosaccharides. It is the major component of endothelial and epithelial cell surface carbohydrate.

Aplicação

Lectin from Lycopersicon esculentum (tomato) has been used:
  • for immunofluorescence staining
  • for the quantification of vascular perfusion
  • for the evaluation of gel perfusion efficiency

Ações bioquímicas/fisiológicas

Lectin has anti-cancer, anti-human immunodeficiency virus (anti-HIV), anti-microbial infection and blocks mucosal atrophy. It reduces type 2 diabetes and obesity, stimulates nutrient absorption and drug targeting. It is used to stain the vascular tree in the spinal cord and brain of animals. Lectin agglutinates cells and precipitates polysaccharides and glycoproteins.
LEA is not blood group specific, but has an affinity for N-acetyl-β-D-glucosamine oligomers. The lectin is a glycoprotein containing approx. equal amounts of protein and carbohydrate and is reported to inhibit the mitogenic activity of phytohemagglutinin from Phaseolus vulgaris. This lectin binds endothelial cells and is used to visualize the microvasculature.

Embalagem

Sold on the basis of mg active conjugate.

forma física

Solution in 10 mM HEPES, 0.15 M NaCl, pH 7.5, containing 0.1 mM Ca2+, 0.08% sodium azide and 5 mg/mL β-cyclodextrin.

Nota de análise

Agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 7.3, of a 1 mg/ml solution. This activity is the lowest concentration to agglutinate a 2% suspension of human erythrocytes after 1 hour incubation at 25 °C.

Código de classe de armazenamento

12 - Non Combustible Liquids

Classe de risco de água (WGK)

WGK 2

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Scientific reports, 8(1), 12573-12573 (2018)
Lycopersicon esculentum lectin: an effective and versatile endothelial marker of normal and tumoral blood vessels in the central nervous system
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European Journal of Histochemistry, 48(4), 423-428 (2009)
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Artigos

Lectin Selection Guide: A Useful Guide for Selecting the Right Lectin

Find the right lectin for your research with our lectin selection guide, organized by lectin source/species, carbohydrate specificity, blood group specificity, and more.

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