I5784

Ibandronate sodium salt

≥97% (NMR), solid

• Sinônimo(s): (1-Hydroxy-3-(methylpentylamino)propylidene)bisphosphonic acid sodium, Bondronat
• Fórmula empírica (Notação de Hill): C₉H₂₂NNaO₇P₂
• Número CAS: 138844-81-2
• Peso molecular: 341.21
• Número MDL: MFCD07197214
• Código UNSPSC: 41106300
• ID de substância PubChem: 329815388
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥97% (NMR)
• Formulário: solid
• condição de armazenamento: protect from light
• cor: white
• solubilidade: H₂O: >10 mg/mL
• originador: Roche
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: [Na+].CCCCCN(C)CCC(O)(P(O)(O)=O)P(O)([O-])=O
• InChI: 1S/C9H23NO7P2.Na/c1-3-4-5-7-10(2)8-6-9(11,18(12,13)14)19(15,16)17;/h11H,3-8H2,1-2H3,(H2,12,13,14)(H2,15,16,17);/q;+1/p-1
• chave InChI: LXLBEOAZMZAZND-UHFFFAOYSA-M
• Informações sobre genes: human ... FDPS(2224)

Descrição

Aplicação

Ibandronate sodium salt has been used to study its effect on the proliferation and ultrastructure of Leishmania and Giardia by the generation of concentration curves.[1] It has also been used to elucidate the route by which nitrogen-containing bisphosphonates (N-BPs) enter the cytosol and inhibit their molecular target.[2]

Ações bioquímicas/fisiológicas

Ibandronate is a nitrogen-containing bisphosphonate (N-BP).[1] It potentially inhibits mevalonate pathway in osteoclasts. Thus, ibandronate is effectively used to treat osteoporosis and other bone-related diseases.[2]

Ibandronate sodium inhibits farnesyl diphosphate synthase (IC₅₀ = 20 nM). Ibandronate sodium is also a bone resorption inhibitor. It has been investigated for in vitro anti-tumor effects, such as apoptosis induction, inhibitor of cell growth, inhibition of invasive behavior, and inhibition of angiogenesis and for its in vivo role in various cancers including breast and prostate cancers.

Ibandronate sodium is a farnesyl diphosphate synthase inhibitor (IC₅₀ = 20 nM); also a bone resorption inhibitor.

Características e benefícios

This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable