SML0223

Zoledronic acid monohydrate

≥98% (HPLC)

• Sinônimo(s): P,P′-[1-Hydroxy-2-(1H-imidazol-1-yl)ethylidene]bisphosphonic acid monohydrate, Zoledronate monohydrate, [1-hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid) monohydrate
• Fórmula empírica (Notação de Hill): C₅H₁₀N₂O₇P₂·H₂O
• Número CAS: 165800-06-6
• Peso molecular: 290.10
• Número MDL: MFCD08448695
• Código UNSPSC: 12352204
• ID de substância PubChem: 329825242
• NACRES: NA.77

Propriedades

• Ensaio: ≥98% (HPLC)
• forma: powder
• condição de armazenamento: desiccated; protect from light
• cor: white to beige
• solubilidade: H₂O: ≥2 mg/mL
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: O.OC(Cn1ccnc1)(P(O)(O)=O)P(O)(O)=O
• InChI: 1S/C5H10N2O7P2.H2O/c8-5(15(9,10)11,16(12,13)14)3-7-2-1-6-4-7;/h1-2,4,8H,3H2,(H2,9,10,11)(H2,12,13,14);1H2
• chave InChI: FUXFIVRTGHOMSO-UHFFFAOYSA-N

Descrição

Aplicação

Zoledronic acid monohydrate has been used:

• as an inhibitor for cell proliferation in glioblastoma, breast cancer tumor and prostate cancer cell line LAPC4
• as a conjugate with D,L-lactide 75: glycolide 25 (PLGA) to analyze its bone formation functionality in distal femur
• as an inhibitor for farnesyl diphosphate synthase enzyme in glioblastoma cells

Ações bioquímicas/fisiológicas

Zoledronic acid (zoledronate) is a bisphosphonate bone resorption inhibitor, an inhibitor of farnesyl diphosphate (FPP) synthase which results in downstream inhibition of osteoclast activity and reduced bone resorption and turnover. It has been used to treat postmenopausal osteoporosis, Paget′s disease, hypercalcemia, and along with cancer chemotherapy to treat bone damage caused by cancer that has spread to the bones.

Nota de preparo

This product is extremely unstable in solution and should be used shortly after reconstitution. If storage of the solution is necessary it can be held at 2-8ºC for no more than 24 hours.

Informações de segurança

• Pictogramas: GHS07
• Palavra indicadora: Warning
• Frases de perigo: H315,H319,H335
• Declarações de precaução: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Classificações de perigo: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Órgãos-alvo: Respiratory system
• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable