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I4161

Sigma-Aldrich

IL-2 mouse

≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture

Sinônimo(s):

IL-2, Interleukin-2, T-cell growth factor, mIL-2

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20 μG
R$ 1.415,00

R$ 1.415,00

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20 μG
R$ 1.415,00

About This Item

Número MDL:
MFCD00164816
Código UNSPSC:
12352202
NACRES:
NA.77

R$ 1.415,00

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Nome do produto

Interleukin-2 from mouse, IL-2, recombinant, expressed in E. coli, carrier free

fonte biológica

mouse

Nível de qualidade

200

recombinante

expressed in E. coli

Ensaio

≥97% (SDS-PAGE)

Formulário

lyophilized powder

potência

≤0.2 ng/mL ED50

qualidade

endotoxin tested

peso molecular

17.2 kDa

embalagem

pkg of 5X20 μg
pkg of 20 μg

técnica(s)

cell culture | mammalian: suitable

Impurezas

≤0.200ng/ml

cor

white

nº de adesão UniProt

P04351

Condições de expedição

dry ice

temperatura de armazenamento

−20°C

Informações sobre genes

mouse ... Il2(16183)

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Categorias relacionadas

Ações bioquímicas/fisiológicas

Interleukin-2 (IL-2) is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. Recombinant human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfide bond.

forma física

Lyophilized with no additives.

Reconstituição

Centrifuge vial prior to opening. Reconstitute the contents of the vial in water to a concentration range of 0.1-1.0 mg/mL.
IL-2 is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions which are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfide bond.

Pictogramas

Exclamation mark
GHS07

Palavra indicadora

Warning

Frases de perigo

H319,H335

Classificações de perigo

Eye Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

10 - Combustible liquids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
0000245090
0000245090
0000139713
059M4121V
11190317

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Sigma-Aldrich

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Joaquin De Haro et al.
Journal of vascular surgery, 62(6), 1625-1631 (2014-07-22)
This study assessed the effect of cellular and humoral autoimmune response inhibition after immunization with β2-glycoprotein I (β2-GPI) and the effect of immunomodulation with interleukin (IL)-2 and IL-10 in the development of early atherosclerotic vascular lesion in a murine model.
Nabil Ahmed et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 33(15), 1688-1696 (2015-03-25)
The outcome for patients with metastatic or recurrent sarcoma remains poor. Adoptive therapy with tumor-directed T cells is an attractive therapeutic option but has never been evaluated in sarcoma. We conducted a phase I/II clinical study in which patients with
Fang-Ting Lu et al.
Journal of autoimmunity, 61, 62-72 (2015-06-15)
Thymic CD4(+) FoxP3(+) regulatory T (Treg) cells are critical for the development of immunological tolerance and immune homeostasis and requires contributions of both thymic dendritic and epithelial cells. Although B cells have been reported to be present within the thymus
X Han et al.
Cell death and differentiation, 21(11), 1758-1768 (2014-07-19)
IL-17 is one of the most potent and most actively investigated proinflammatory cytokines. In this study, we examined the effect of IL-17 on mesenchymal stem cells (MSCs) under the influence of inflammatory cytokines. Ironically, IL-17 dramatically enhanced the immunosuppressive effect
Larisa Kizima et al.
PloS one, 9(4), e94547-e94547 (2014-04-18)
Prevalent infection with human herpes simplex 2 (HSV-2) or human papillomavirus (HPV) is associated with increased human immunodeficiency virus (HIV) acquisition. Microbicides that target HIV as well as these sexually transmitted infections (STIs) may more effectively limit HIV incidence. Previously
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