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I2764

Sigma-Aldrich

ML-7

powder

Sinônimo(s):

1-(5-Iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride

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About This Item

Fórmula empírica (Notação de Hill):
C15H17IN2O2S · HCl
Número CAS:
110448-33-4
Peso molecular:
452.74
Número MDL:
MFCD00065524
Código UNSPSC:
12352200
ID de substância PubChem:
24278490
NACRES:
NA.77

Ensaio

≥98% (TLC)

forma

powder

cor

white

solubilidade

ethanol: water (1:1): 10 mg/mL, clear, colorless to faintly yellow

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

Cl.Ic1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3

InChI

1S/C15H17IN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H

chave InChI

KDDALCDYHZIZMH-UHFFFAOYSA-N

Informações sobre genes

human ... MYLK(4638) , MYLK2(85366)

Aplicação

ML-7 has been used as a myosin light chain kinase (MLCK) inhibitor in various experiments.

Ações bioquímicas/fisiológicas

Selective myosin light chain kinase inhibitor.

Características e benefícios

This compound is featured on the Ca/CaMKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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Sigma-Aldrich

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Sigma-Aldrich

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Nocodazole

Kristopher E Kubow et al.
Scientific reports, 7(1), 14380-14380 (2017-11-01)
Contact guidance-cell polarization by anisotropic substrate features-is integral to numerous physiological processes; however the complexities of its regulation are only beginning to be discovered. In particular, cells polarize to anisotropic features under non-muscle myosin II (MII) inhibition, despite MII ordinarily
Inhibition of myosin light chain kinase can be targeted for the development of new therapies against herpes simplex virus type-1 infection
Antoine TE and Shukla D
Antiviral Therapy, 19, 15-29 (2014)
Zasp/Cypher internal ZM-motif containing fragments are sufficient to co-localize with alpha-actinin?Analysis of patient mutations
Klaavuniemi T and Ylanne J
Experimental Cell Research, 312(8), 1299-1311 (2006)
M Makishima et al.
FEBS letters, 287(1-2), 175-177 (1991-08-05)
Inhibitors of myosin light chain kinase, 1-(5-chloronaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-9) and 1-(5-iodonaphthalene-1-sulfonyl)-1H-hexahydro-1,4-diazepine hydrochloride (ML-7), induced Nitroblue tetrazolium reducing activity, lysozyme activity and morphological maturation of human monoblastic U937, THP-1 and promyelocytic HL-60 cells, but not of erythroblastic K562 cells. However, three
Chuanjun Huang et al.
Molecular medicine reports, 17(5), 6293-6300 (2018-03-08)
Previous studies have indicated that smooth muscle myosin light chain kinase (MLCK) has a prominent role in the regulation of smooth muscle contraction, which tends to be upregulated in asthma. In recent years, numerous studies have reported that MLCK is
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