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I1774

Sigma-Aldrich

Iturin A from Bacillus subtilis

≥95% (HPLC), suitable for microbiological culture

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About This Item

Número CAS:
52229-90-0
Número MDL:
MFCD01094135
Código UNSPSC:
12352202
NACRES:
NA.61

product name

Iturin A from Bacillus subtilis, ≥95% (HPLC)

fonte biológica

Bacillus subtilis

Nível de qualidade

200

Ensaio

≥95% (HPLC)

forma

powder

técnica(s)

microbiological culture: suitable

cor

white to yellow

solubilidade

ethanol: soluble 9.80-10.20 mg/mL

espectro de atividade do antibiótico

fungi

Modo de ação

cell membrane | interferes

temperatura de armazenamento

2-8°C

Aplicação

Iturin A was used in the study of Bacillomycin D (an iturin with antifungal activity against Aspergillus flavus).

Ações bioquímicas/fisiológicas

IturinA exhibits strong antifungal activity against pathogenic yeast and fungi. It interacts with the cytoplasmic membrane of the target cell forming ion conducting pores. Its mode of action could be attributed to its interaction with sterols and phospholipids. The compound causes the release of exo-vesicles from human erythrocytes.

Outras notas

A family of lipopeptides characterized by a heptapeptide cyclized with a C13-C17 β-amino fatty acid. Composed mainly of C14-C15 β-amino acids.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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M A Klich et al.
Mycopathologia, 127(2), 123-127 (1994-08-01)
The removal of many synthetic fungicides from the market has created a demand for new, environmentally safe fungicides. Iturin A, a cyclic lipopeptide produced by Bacillus subtilis, has strong antifungal properties and low mammalian toxicity. To determine the efficacy of
Scott W Pryor et al.
Journal of agricultural and food chemistry, 55(23), 9530-9536 (2007-10-24)
Partial least squares (PLS) regression modeling was used to relate the antifungal activity of Bacillus subtilis solid-state fermentation extracts to the individual high-performance liquid chromatography (HPLC) peaks from those extracts. A model was developed that predicted bioassay inhibition based on
R Maget-Dana et al.
Toxicology, 87(1-3), 151-174 (1994-02-28)
Iturins are a family of lipopeptides extracted from the culture media of various strains of Bacillus subtilis. These amphiphilic compounds are characterized by a peptide ring of seven amino acid residues including an invariable D-Tyr2, with the constant chiral sequence
Thimon, L., et al.
Cytobios, 79, 96-96 (1994)
Nopporn Thasana et al.
FEBS letters, 584(14), 3209-3214 (2010-06-15)
Subtulene A, a new cyclic lipopeptide, was isolated from the culture broth of Bacillus subtilis SSE4. This antibiotic compound contained the seven common alpha-amino acids, L-Asn-1, D-Tyr-2, D-Asn-3, L-Gln-4, L-Pro-5, D-Asn-6, L-Ser-7 and the unique beta-amino acid-8 present in the
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