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H5257

Sigma-Aldrich

Hispidin

solid, ≥98% (HPLC)

Sinônimo(s):

6-(3,4-dihydroxystyrl)-4-hydroxy-2-pyrone

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About This Item

Fórmula empírica (Notação de Hill):
C13H10O5
Número CAS:
555-55-5
Peso molecular:
246.22
Número MDL:
MFCD01866972
Código UNSPSC:
12352200
ID de substância PubChem:
24278468
NACRES:
NA.77

fonte biológica

synthetic (organic)

Ensaio

≥98% (HPLC)

forma

solid

condição de armazenamento

protect from light

cor

yellow to brown

pf

237.5-238.5  °C

solubilidade

DMSO: >10 mg/mL

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

OC1=CC(/C=C/C(O2)=CC(O)=CC2=O)=CC=C1O

InChI

1S/C13H10O5/c14-9-6-10(18-13(17)7-9)3-1-8-2-4-11(15)12(16)5-8/h1-7,14-16H/b3-1+

chave InChI

SGJNQVTUYXCBKH-HNQUOIGGSA-N

Informações sobre genes

human ... PRKACB(5567) , PRKAR2B(5577) , PRKCB(5579)

Descrição geral

Hispidin is a phenolic compound, that is obtained from a medicinal mushroom, Phellinus linteus.

Ações bioquímicas/fisiológicas

Hispidin exhibits robust antioxidant, anticancer and antidiabetic properties. It has the ability to guard against peroxynitrite-mediated cytotoxicity, DNA damage and the development of hydroxyl radicals.
Potent inhibitor of protein kinase Cβ, cytotoxic for cancer cells.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

No data available

Ponto de fulgor (°C)

No data available

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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Sirosh M Bokhari et al.
The Journal of investigative dermatology, 126(2), 460-467 (2005-12-24)
Activation of protein kinase C (PKC) induces phenotypic changes in the morphology of microvascular endothelial cells that affect major functions of the microvasculature. These functions include the first stages of sprouting in angiogenesis, cell migration following wounding, and vascular permeability.
Prabodh Risal et al.
Journal of natural products, 75(10), 1683-1689 (2012-10-03)
In this study the protective effects of davallialactone (1), isolated from Inonotus xeranticus, have been examined against carbon tetrachloride (CCl₄-induced acute liver injury. Mice received subcutaneous injection of 1 (2.5, 5, and 10 mg/kg) for three days before CCl₄ injection
Alvaro Macias et al.
International journal of molecular sciences, 22(3) (2021-02-13)
KV1.5 channel function is modified by different regulatory subunits. KVβ1.3 subunits assemble with KV1.5 channels and induce a fast and incomplete inactivation. Inhibition of PKC abolishes the KVβ1.3-induced fast inactivation, decreases the amplitude of the current KV1.5-KVβ1.3 and modifies their
C Gonindard et al.
Cell biology and toxicology, 13(3), 141-153 (1997-03-01)
The trypanocidal activity of naturally occurring 6-(3,4-dihydroxystyryl)-4-hydroxy-2-pyrone (hispidin) prompted us to examine its cytotoxic activity toward normal and cancerous cells in culture. Hispidin synthesized in our laboratory to a high degree of purity (checked by 1H and 13C NMR spectroscopy)
Wei Chen et al.
Chemico-biological interactions, 199(3), 137-142 (2012-07-24)
Oxidative stress plays an important role in the progression of many chronic diseases including cardiovascular diseases, diabetes, cancer and neurodegenerative disorders. One such mediator of oxidative stress is peroxynitrite, which is highly toxic to cultured neurons and astrocytes, and has
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