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H4002

Sigma-Aldrich

DL-3-Hydroxynorvaline

≥98% (TLC)

Sinônimo(s):

HNV, α-Amino-β-hydroxyvaleric acid, 2-Amino-3-hydroxypentanoic acid, 3-Hydroxy-2-aminopentanoic acid, DL-β-Hydroxynorvaline

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About This Item

Fórmula empírica (Notação de Hill):
C5H11NO3
Número CAS:
2280-42-4
Peso molecular:
133.15
Beilstein:
1722350
Número MDL:
MFCD00010516
Código UNSPSC:
12352209
eCl@ss:
32160406
ID de substância PubChem:
24895609
NACRES:
NA.26

product name

DL-3-Hydroxynorvaline, ≥98% (TLC)

Ensaio

≥98% (TLC)

forma

powder

cor

white

aplicação(ões)

cell analysis

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

CCC(O)C(N)C(O)=O

InChI

1S/C5H11NO3/c1-2-3(7)4(6)5(8)9/h3-4,7H,2,6H2,1H3,(H,8,9)

chave InChI

LGVJIYCMHMKTPB-UHFFFAOYSA-N

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Categorias relacionadas

Ações bioquímicas/fisiológicas

3-Hydroxynorvaline (HNV) is a microbial, α amino acid threonine analogue which has antiviral activity (herpes virus) and is toxic to mammalian cells (embryotoxic and teratogenic) presumably via incorporation into proteins. 3-Hydroxynorvaline may be used as an unnatural amino acid to study the fidelity of protein translation at the level of acyl-tRNA editing. 3-Hydroxynorvaline may also be used to study enzymes and molecules involved in threonine metabolism.

Pictogramas

CorrosionExclamation mark
GHS05,GHS07

Palavra indicadora

Danger

Frases de perigo

H315,H318,H335

Classificações de perigo

Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

Órgãos-alvo

Respiratory system

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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F A Barile et al.
Archives of biochemistry and biophysics, 270(1), 294-301 (1989-04-01)
Amino acid substitutions in collagen that impair folding of the triple helix result in significant increases in intracellular degradation of newly synthesized collagen. We have studied the effects of agents that cause other kinds of defects in collagen: hydroxynorvaline, a
G Hortin et al.
The Journal of biological chemistry, 255(15), 7051-7054 (1980-08-10)
The proteolytic processing of rat pre-prolactin (Pre-Prl) to prolactin in isolated hemipituitaries was inhibited by the threonine analog, beta-hydroxynorvaline (Hnv). Pre-Prl accumulated as a major labeled intracellular product, even during pulse labeling longer than 2 h, but it was not
P A Docherty et al.
The Journal of biological chemistry, 260(19), 10847-10855 (1985-09-05)
The threonine analog beta-hydroxynorvaline (Hnv) is an inhibitor of asparagine-linked glycosylation. In the presence of the analog hepatocytes synthesized immunoreactive alpha 1-acid glycoprotein with 0-6 oligosaccharide chains. Pulse-chase experiments were conducted to compare the rates of secretion of alpha 1-acid
C M Alarcón et al.
Molecular and cellular biology, 17(10), 5968-5975 (1997-10-07)
The peptidyl-prolyl isomerase FKBP12 was originally identified as the intracellular receptor for the immunosuppressive drugs FK506 (tacrolimus) and rapamycin (sirolimus). Although peptidyl-prolyl isomerases have been implicated in catalyzing protein folding, the cellular functions of FKBP12 in Saccharomyces cerevisiae and other
Y J Gordon et al.
Current eye research, 5(2), 93-99 (1986-02-01)
The present study examined the anti-herpetic effect of the glycoprotein inhibitors, hydroxynorvaline and 2-deoxyglucose, alone and in combination with trifluridine on murine ocular herpes. Following ocular inoculation with a large dose of HSV-1 RE strain (10(6) pfu), ICR mice were
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