G8415

L-Glutamic acid

98.5-100.5%, suitable for cell culture, non-animal source, meets EP testing specifications

• Sinônimo(s): (S)-2-Aminopentanedioic acid, Glu
• Fórmula linear: HO₂CCH₂CH₂CH(NH₂)CO₂H
• Número CAS: 56-86-0
• Peso molecular: 147.13
• Beilstein: 1723801
• Número CE: 200-293-7
• Número MDL: MFCD00002634
• Código UNSPSC: 12352209
• eCl@ss: 32160406
• ID de substância PubChem: 24895340
• NACRES: NA.26

Propriedades

• Nome do produto: L-Glutamic acid, from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-100.5%
• fonte biológica: non-animal source
• Nível de qualidade: 300
• Agency: meets EP testing specifications
• Ensaio: 98.5-100.5%
• Formulário: powder
• técnica(s): cell culture | mammalian: suitable
• Impurezas: endotoxin, tested
• cor: white
• pf: 205 °C (dec.) (lit.)
• solubilidade: 1 M HCl: 100 mg/mL
• densidade: 1.54 g/cm³ at 20 °C
• traços de ânion: chloride (Cl^-): ≤200 ppm; sulfate (SO₄^2-): ≤200 ppm
• traços de cátion: As: ≤1 ppm, passes test; Fe: ≤10 ppm, passes test; NH₄⁺: ≤200 ppm, passes test
• aplicação(ões): pharmaceutical (small molecule)
• cadeia de caracteres SMILES: N[C@@H](CCC(O)=O)C(O)=O
• InChI: 1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
• chave InChI: WHUUTDBJXJRKMK-VKHMYHEASA-N
• Informações sobre genes: human ... CCR2(1231) , GRIA1(2890) , GRIA2(2891) , GRIA4(2893) , GRIK1(2897) , GRIK2(2898) , GRIK3(2899) , GRIK5(2901) , GRIN2B(2904) , GRM2(2912) , SLC1A1(6505) , SLC1A2(6506) ; rat ... Gria1(50592) , Grik1(29559) , Grik2(54257) , Grik4(24406) , Grin2a(24409) , Grm1(24414) , Grm2(24415) , Grm3(24416) , Grm4(24417) , Grm5(24418) , Grm6(24419) , Grm7(81672) , Slc1a2(29482)

Descrição

Aplicação

L-Glutamic acid has been used as a supplement in for cell culture media to culture hippocampal neurons and hT-PA (human tissue plasminogen activation) producing cell line.[1][2][3]

Ações bioquímicas/fisiológicas

Glutamic acid, or glutamate, the salt form of glutamic acid, functions as a neurotransmitter and also serves as a precursor to other neurotransmitters such as γ-aminobutyric acid.[4] Glutamic acid also plays a key role in many metabolic pathways, that controls growth, reproduction, maintenance and immunity.[5] It is converted to α-ketoglutarate, a key component of the TCA (tricarboxylic acid) cycle, and a precursor for the biosynthesis of nucleic acids and certain amino acids.[5][6] In cells, glutamine is converted to glutamate by the enzyme glutaminase.[6] Glutamine serves as a source of energy for rapidly dividing cells comprising lymphocytes, enterocytes, macrophages and tumors. Glutamine mediates protein turnover via cellular mTOR (mammalian target of rapamycin) signaling. It is also known to be associated with the inhibition of apoptosis.[5]

An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA).

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 1
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)