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F5557

Sigma-Aldrich

Fasentin

≥98% (HPLC)

Sinônimo(s):

N-[4-Chloro-3-(trifluoromethyl)phenyl]-3-oxobutanamide

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5 MG
R$ 591,00
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About This Item

Fórmula empírica (Notação de Hill):
C11H9ClF3NO2
Número CAS:
392721-37-8
Peso molecular:
279.64
Número MDL:
MFCD01001285
Código UNSPSC:
12352200
ID de substância PubChem:
329799713
NACRES:
NA.77

R$ 591,00

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Nível de qualidade

100

Ensaio

≥98% (HPLC)

Formulário

powder

cor

white to off-white

solubilidade

DMSO: >10 mg/mL

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

CC(=O)CC(=O)Nc1ccc(Cl)c(c1)C(F)(F)F

InChI

1S/C11H9ClF3NO2/c1-6(17)4-10(18)16-7-2-3-9(12)8(5-7)11(13,14)15/h2-3,5H,4H2,1H3,(H,16,18)

chave InChI

GNYIJZMBLZXJEJ-UHFFFAOYSA-N

Aplicação

Fasentin has been used as a glucose transporter (GLUT1) inhibitor to assess its effects on the vulnerability of a wide range of triple-negative breast cancer (TNBC) cell lines[1] and to study its effects on cytotoxic drugs induced by hydrocortisone (HC).[2]

Ações bioquímicas/fisiológicas

Fasentin is a novel inhibitor of glucose uptake, GluT1 inhibitor. Fasentin is a novel inhibitor of glucose uptake that sensitizes cells to FAS-induced cell death. Fasentin selectively sensitized to death ligands, but did not decrease FLIP expression. It alters expression of genes associated with nutrient and glucose deprivation. Fasentin interacted with a unique site in the intracellular channel of the glucose transport protein GLUT1.
Fastentin is a novel inhibitor of glucose uptake, GluT1 inhibitor.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

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Certificados de análise (COA)

Lot/Batch Number
0000143519
0000143514
0000094866
0000094867
0000064238

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Eleni Louka et al.
The Journal of experimental medicine, 218(2) (2021-01-09)
Juvenile myelomonocytic leukemia (JMML) is a poor-prognosis childhood leukemia usually caused by RAS-pathway mutations. The cellular hierarchy in JMML is poorly characterized, including the identity of leukemia stem cells (LSCs). FACS and single-cell RNA sequencing reveal marked heterogeneity of JMML
Qin Wu et al.
Nature communications, 11(1), 4205-4205 (2020-08-23)
Triple negative breast cancer (TNBC) is a deadly form of breast cancer due to the development of resistance to chemotherapy affecting over 30% of patients. New therapeutics and companion biomarkers are urgently needed. Recognizing the elevated expression of glucose transporter
Dominik Kraus et al.
Cellular and molecular life sciences : CMLS, 73(6), 1287-1299 (2015-09-27)
In our study, ghrelin was investigated with respect to its capacity on proliferative effects and molecular correlations on oral tumor cells. The presence of all molecular components of the ghrelin system, i.e., ghrelin and its receptors, was analyzed and could
Antonio Celentano et al.
Journal of cellular physiology, 234(3), 2013-2020 (2018-09-22)
Synthetic corticosteroids are routinely administered during the treatment of several diseases, including malignancies. However, recent evidence suggests that corticosteroids may have tumor-promoting effects, particularly in epithelial neoplasms. Our aim was to assess the role of the recently characterized cancer-associated glucocorticoid

Artigos

Aerobic Glycolysis and the Warburg Effect

Warburg effect enhances glucose to lactate conversion in tumor cells, regardless of oxygen levels; impacting cancer metabolism since 1924.

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