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E1631

Sigma-Aldrich

β-Estradiol 17-valerate

≥98% (HPLC), powder

Sinônimo(s):

1,3,5(10)-Estratriene-3,17β-diol 17-pentanote

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About This Item

Fórmula empírica (Notação de Hill):
C23H32O3
Número CAS:
979-32-8
Peso molecular:
356.50
Beilstein:
2480357
Número CE:
213-559-2
Número MDL:
MFCD00056541
Código UNSPSC:
41116107
ID de substância PubChem:
24894423
NACRES:
NA.77
Preço e disponibilidade não estão disponíveis no momento.

Nome do produto

β-Estradiol 17-valerate, ≥98%

fonte biológica

synthetic

Ensaio

≥98%

Formulário

powder

técnica(s)

ELISA: suitable

solubilidade

acetone: 25 mg/mL, hazy, colorless

Condições de expedição

ambient

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

CCCCC(=O)OC1CCC2C3CCc4cc(O)ccc4C3CCC12C

InChI

1S/C23H32O3/c1-3-4-5-22(25)26-21-11-10-20-19-8-6-15-14-16(24)7-9-17(15)18(19)12-13-23(20,21)2/h7,9,14,18-21,24H,3-6,8,10-13H2,1-2H3

chave InChI

RSEPBGGWRJCQGY-UHFFFAOYSA-N

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Descrição geral

β-Estradiol 17-valerate is a synthetic estrogen.[1]

Aplicação

β-Estradiol 17-valerate has been used:
  • in an in-vivo assay, to synchronize the estrus cycle in athymic nude mice, to study the effect of recombinant pigment epithelium-derived factor (rPEDF) on induced ectopic fibroid lesions[2]
  • to study the influence of ovarian hormones on type II cGMP-dependent protein kinase (Prkg2) expression in mice[3]
  • to induce growth of estrogen-dependent tumor cells in athymic nude mice to establish a breast cancer mouse model[4]

Ações bioquímicas/fisiológicas

Estradiol valerate is observed to be useful for treating menopausal climacteric symptoms.[5] β-Estradiol 17-valerate is used as a source of 17β-estradiol (E2) in in vitro fertilization, hormone replacement therapy, contraceptive drugs, to study reproductive disorders in animal models.[1] It serves as growth promoter in animal farming. β-Estradiol 17-valerate is also used to culture single-sex population among fish. Studies in rats show that β-Estradiol 17-valerate has negative effects on the estrus cycle pattern.[1]

Pictogramas

Health hazardEnvironment
GHS08,GHS09

Palavra indicadora

Warning

Frases de perigo

H351,H361fd,H362,H410

Classificações de perigo

Aquatic Chronic 1 - Carc. 2 - Lact. - Repr. 2

Código de classe de armazenamento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe de risco de água (WGK)

WGK 3

Equipamento de proteção individual

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Certificados de análise (COA)

Lot/Batch Number
BCCK7284
BCCK2269
BCCJ6905
BCCG7646
BCCD9978

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Christophe Blockeel et al.
Reproductive biomedicine online, 24(3), 272-280 (2012-02-03)
This randomized controlled trial analyses the ability to control the oocyte retrieval schedule of gonadotrophin-releasing hormone antagonist cycles through the administration of oestradiol valerate during the luteo-follicular transition period prior to the initiation of ovarian stimulation. Eighty-six women undergoing ovarian
Huib A A M Van Vliet et al.
The Cochrane database of systematic reviews, (11)(11), CD009038-CD009038 (2011-11-11)
Quadriphasic oral contraceptives have been developed to reduce the adverse effects of oral contraceptives and are presented as more physiological since they mimic the natural cycle. However, suggested disadvantages of quadriphasic oral contraceptives include a possible increased risk of pill-taking
Kevin Hollevoet et al.
Oncotarget, 9(17), 13623-13636 (2018-03-24)
Antibody gene transfer presents an appealing alternative to conventional antibody protein therapy. This pre-clinical study evaluates the impact of various parameters on the pharmacokinetics and efficacy of in vivo expressed DNA-based anti-HER2 monoclonal antibodies (mAbs), newly engineered and delivered via
Elizabeth Micks et al.
Women's health (London, England), 7(5), 513-524 (2011-09-02)
Estradiol valerate and dienogest have been combined to create a novel four-phasic oral contraceptive pill effective for both pregnancy prevention and treatment of heavy menstrual bleeding. This formulation represents the only oral contraceptive pill available in the USA containing an
Gonzalo Cruz et al.
Fertility and sterility, 98(5), 1283-1290 (2012-08-03)
To investigate the developmental window in which E(2) exposure produces irreversible changes in ovarian function resulting in polycystic ovary. Basic experimental study. University animal laboratory. Thirty Sprague-Dawley rats were administered a single E(2) valerate dose (10 mg/kg of weight) at
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