E0287
Carboxylesterase 1 isoform b human
recombinant, expressed in baculovirus infected BTI insect cells
Sinônimo(s):
Carboxylesterase 1 human, carboxylesterase, esterase
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About This Item
Preço e disponibilidade não estão disponíveis no momento.
Produtos recomendados
recombinante
expressed in baculovirus infected BTI insect cells
Nível de qualidade
Formulário
liquid
atividade específica
≥500 units/mg protein
concentração
5 mg/mL
peso
(0.5 ml)
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
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Descrição geral
Carboxylesterase (CE) belongs to serine hydrolase family.[1] It is widely present in the human body. Five isoforms of carboxylesterase is present in humans.[2] It is encoded by CES1 gene mapped to 16q22.2 in human chromosome.[3]
Carboxylesterase 1 is a member of a large multigene carboxylesterase family. These enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. This enzyme is known to hydrolyze aromatic and aliphatic esters and is necessary for cellular cholesterol esterification. It may also play a role in detoxification in the lung and/or protection of the central nervous system from ester or amide compounds.
Aplicação
Carboxylesterase 1 isoform b human has been used in the reaction to convert Amplex red to resorufin in horse radish peroxidase and oxygen independent manner.[1] It has also been used in the development of an emission ratiometric two-photon probe (SE1) for quantitation in situ.[2]
Delivers high catalytic activity, ideal for robust high-throughput screening assays including drug-drug interaction studies, and pharmacokinetic studies for evaluating pro-drugs and non-CYP pathways of elimination.
Ações bioquímicas/fisiológicas
Carboxylesterase (CE) is implicated in drug metabolism in liver and hepatic steatosis. Deficiency of CE in humans causes obesity, hyperlipidemia, insulin insensitivity, and cancer.[2]
Definição da unidade
One unti will hydrolyze one nanomole of 4-nitrophenyl acetate per minute at pH 7.4 at 37°C
Palavra indicadora
Danger
Frases de perigo
Declarações de precaução
Classificações de perigo
Resp. Sens. 1
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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