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D9439

Sigma-Aldrich

Desmosine chloride

from bovine, 99.5%±0.2%

Sinônimo(s):

DES

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About This Item

Fórmula empírica (Notação de Hill):
C24H40ClN5O8
Número CAS:
10019-68-8
Peso molecular:
562.06
Número MDL:
MFCD12910449
Código UNSPSC:
12352202
ID de substância PubChem:
329798901
NACRES:
NA.56

fonte biológica

bovine

Nível de qualidade

100

Ensaio

99.5%±0.2%

forma

lyophilized powder

purificado por

chromatography (and purified by solvent extraction)

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

[Cl-].NC(CCCC[n+]1cc(CCC(N)C(O)=O)c(CCCC(N)C(O)=O)c(CCC(N)C(O)=O)c1)C(O)=O

InChI

1S/C24H39N5O8.ClH/c25-17(21(30)31)5-1-2-11-29-12-14(7-9-19(27)23(34)35)16(4-3-6-18(26)22(32)33)15(13-29)8-10-20(28)24(36)37;/h12-13,17-20H,1-11,25-28H2,(H3-,30,31,32,33,34,35,36,37);1H

chave InChI

FUPMLZCXPJSGPV-UHFFFAOYSA-N

Descrição geral

Each vial contains 1 μmole of purified desmosine.

Aplicação

Desmosine chloride is often used in assays for free or urinary desmosine as markers for disease states characterized by elastin degradation (e.g., emphysema). Elastin degradation has shown strong correlation with vascular calcification, and pretreatment with aluminum ions can inhibit the binding of matrix metalloproteinase (MMP) to elastin.
Assays for free or urinary desmosine are often used as markers for disease states characterized by elastin degradation (e.g., emphysema). Conversely, excessive levels of incorporated desmosine are indicators of fibrotic conditions (e.g., cirrhosis).

Ações bioquímicas/fisiológicas

Desmosine is a polyfunctional amino acid that forms cross-links in mature elastin.

Atenção

Extremely hygroscopic

Nota de análise

Calibrated by UV and amino acid analysis.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Franca Cocci et al.
The international journal of biochemistry & cell biology, 34(6), 594-604 (2002-04-12)
An enhanced proteolysis of lung interstitium is key event in the pathogenesis of emphysema, a major constituent of chronic obstructive pulmonary disease. To assess whether urinary desmosine and/or hydroxyproline may be used as a marker of lung destruction we studied
M Bailey et al.
The American journal of pathology, 159(6), 1981-1986 (2001-12-26)
Calcification of elastin occurs in many pathological cardiovascular diseases including atherosclerosis. We have previously shown that purified elastin when subdermally implanted in rats undergoes severe calcification and aluminum chloride (AlCl(3)) pretreatment of elastin inhibits calcification. In the present study we
Dina M Basalyga et al.
Circulation, 110(22), 3480-3487 (2004-11-17)
Elastin calcification is a widespread feature of vascular pathology, and circumstantial evidence exists for a correlation between elastin degradation and calcification. We hypothesized that matrix metalloproteinase (MMP)-mediated vascular remodeling plays a significant role in elastin calcification. In the present studies

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