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D5318

Sigma-Aldrich

DCP-LA

≥95% (HPLC), oil

Sinônimo(s):

2-[(2-pentylcyclopropyl)methyl]cyclopropaneoctanoic acid, 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid, FR 236924

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About This Item

Fórmula empírica (Notação de Hill):
C20H36O2
Número CAS:
28399-31-7
Peso molecular:
308.50
Número MDL:
MFCD09265251
Código UNSPSC:
12352200
ID de substância PubChem:
24724463
NACRES:
NA.77

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Ensaio

≥95% (HPLC)

Formulário

oil

cor

clear

solubilidade

DMSO: >2 mg/mL

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

CCCCCC1CC1CC2CC2CCCCCCCC(O)=O

InChI

1S/C20H36O2/c1-2-3-7-10-16-13-18(16)15-19-14-17(19)11-8-5-4-6-9-12-20(21)22/h16-19H,2-15H2,1H3,(H,21,22)

chave InChI

CONYTTFKIUJZOF-UHFFFAOYSA-N

Ações bioquímicas/fisiológicas

DCP-LA is a selective PKC-epsilon (PKC-ε) activator.
DCP-LA is a selective PKC-epsilon (PKC-ε) activator. In the in situ PKC assay with a reversed phase high-performance liquid chromatography, DCP-LA significantly activated PKC in PC-12 cells in a concentration (10 nM-100 μM)-dependent manner, with the maximal effect at 100 nM. DCP-LA has over a 7-fold greater potency for activation of PKC-ε over other PKC isozymes.

Características e benefícios

This compound is featured on the PKC page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
088K4619V
088K46192
088K46191
088K4619
066K4615

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Takeshi Kanno et al.
Journal of lipid research, 47(6), 1146-1156 (2006-03-08)
This study examined the effect of 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA), a newly synthesized linoleic acid derivative with cyclopropane rings instead of cis-double bonds, on protein kinase C (PKC) activity. In the in situ PKC assay with reverse-phase high-performance liquid chromatography, DCP-LA
Takahiro Yaguchi et al.
Neuroreport, 17(1), 105-108 (2005-12-20)
In the water-maze test, the linoleic acid derivative, 8-[2-(2-pentyl-cyclopropylmethyl)-cyclopropyl]-octanoic acid (DCP-LA) (1 mg/kg, intraperitoneally), significantly shortened the prolonged latency for accelerated-senescence-prone mice 8 (SAMP8), reaching a level similar to the latency for accelerated-senescence-resistant mice 1 (SAMR1) as control. In the
Ling-Yu Qiu et al.
Molecular medicine reports, 16(3), 2953-2961 (2017-07-06)
Anion exchanger 3 (AE3) is known to serve crucial roles in maintaining intracellular chloride homeostasis by facilitating the reversible electroneutral exchange of Cl‑ for HCO3‑ across the plasma membrane. Our previous studies reported that sasanquasaponin (SQS) can inhibit hypoxia/reoxygenation (H/R)‑induced
Joshua H K Tam et al.
PloS one, 11(10), e0161445-e0161445 (2016-10-25)
The amyloid hypothesis posits that the production of β-amyloid (Aβ) aggregates leads to neurodegeneration and cognitive decline associated with AD. Aβ is produced by sequential cleavage of the amyloid precursor protein (APP) by β- and γ-secretase. While nascent APP is

Artigos

Protein Kinase C (PKC)

Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins.

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