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D4434

Sigma-Aldrich

Dichloromethylenediphosphonic acid disodium salt

Sinônimo(s):

Cl2MDP, Clodronate disodium, Clodronic acid disodium salt, DMDP

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About This Item

Fórmula linear:
CH2O6Cl2Na2P2
Número CAS:
22560-50-5
Peso molecular:
288.86
Número CE:
245-078-9
Número MDL:
MFCD01632786
Código UNSPSC:
12352106
ID de substância PubChem:
24278371
NACRES:
NA.77

forma

powder

Nível de qualidade

300

solubilidade

water: 49.00-51.00 mg/mL, clear, colorless

temperatura de armazenamento

room temp

cadeia de caracteres SMILES

[Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O

InChI

1S/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2

chave InChI

HJKBJIYDJLVSAO-UHFFFAOYSA-L

Informações sobre genes

rat ... Man2a1(25478) , Si(497756)

Ações bioquímicas/fisiológicas

Analog of pyrophosphate ion that inhibits the osteoclastic activity leading to bone resorption and osteoporosis. The compound is used in cancer research, especially in skeletal metastases and breast carcinoma. When entrapped in liposomes, it is used for macrophage-selective depletion (macrophage "suicide" technique), especially in spleen and liver. Found also to inhibit collagenase and matrix metalloproteinase1.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

Certificados de análise (COA)

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Sigma-Aldrich

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Sigma-Aldrich

41640

Dimetilsulfóxido

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Sigma-Aldrich

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O Teronen et al.
Calcified tissue international, 61(1), 59-61 (1997-07-01)
Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate. The IC50 of clodronate to inhibit MMP-1 is 150 microM. These findings suggest an
Michiko Itoh et al.
PloS one, 8(12), e82163-e82163 (2013-12-19)
Although macrophages are thought to be crucial for the pathogenesis of chronic inflammatory diseases, how they are involved in disease progression from simple steatosis to non-alcoholic steatohepatitis (NASH) is poorly understood. Here we report the unique histological structure termed "hepatic
N Van Rooijen
Journal of immunological methods, 124(1), 1-6 (1989-11-13)
Macrophages form an important cell population involved in numerous immunological processes. Techniques which eliminate these cells, in order to permit 'in vivo' studies of their function are generally imperfect and for that reason we have developed a method using the
Valérie Lebrun et al.
Clinical science (London, England : 1979), 125(11), 501-511 (2013-06-14)
Alcohol consumption is a major cause of liver disease. It also associates with increased cardiovascular risk and Type 2 diabetes. ALD (alcoholic liver disease) and NAFLD (non-alcoholic fatty liver disease) share pathological features, pathogenic mechanisms and pattern of disease progression.
Andrew Chow et al.
The Journal of experimental medicine, 208(2), 261-271 (2011-02-02)
Hematopoietic stem cells (HSCs) reside in specialized bone marrow (BM) niches regulated by the sympathetic nervous system (SNS). Here, we have examined whether mononuclear phagocytes modulate the HSC niche. We defined three populations of BM mononuclear phagocytes that include Gr-1(hi)
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