D3821

Devazepide

≥98% (HPLC), powder

• Sinônimo(s): (S)-N-(2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)indole-2-carboxamide, L-364,718, MK 329
• Fórmula empírica (Notação de Hill): C₂₅H₂₀N₄O₂
• Número CAS: 103420-77-5
• Peso molecular: 408.45
• Número MDL: MFCD00864500
• Código UNSPSC: 12352200
• ID de substância PubChem: 329798778
• NACRES: NA.77

Propriedades

• Nível de qualidade: 100
• Ensaio: ≥98% (HPLC)
• Formulário: powder
• condição de armazenamento: desiccated
• cor: white to off-white
• solubilidade: DMSO: >5 mg/mL
• originador: Merck & Co., Inc., Kenilworth, NJ, U.S.
• temperatura de armazenamento: 2-8°C
• cadeia de caracteres SMILES: CN1C(=O)[C@@H](NC(=O)c2cc3ccccc3[nH]2)N=C(c4ccccc4)c5ccccc15
• InChI: 1S/C25H20N4O2/c1-29-21-14-8-6-12-18(21)22(16-9-3-2-4-10-16)27-23(25(29)31)28-24(30)20-15-17-11-5-7-13-19(17)26-20/h2-15,23,26H,1H3,(H,28,30)/t23-/m1/s1
• chave InChI: NFHRQQKPEBFUJK-HSZRJFAPSA-N

Descrição

Descrição geral

Devazepide is derived from asperlicin by chemical modification and has the benzodiazepine backbone.[1]

Aplicação

Devazepide has been used as a cholecystokinin receptor 1 (CCK1R) antagonist in human embryonic kidney 293T cells[2] and in human pancreatic slices.[3]

Ações bioquímicas/fisiológicas

Devazepide is a CCK1 (CCK-A) receptor antagonist and a CCK8 antagonist.

Devazepide is a CCK1 receptor antagonist.

Devazepide is a cholecystokinin octapeptide (CCK1) (CCK-A) receptor antagonist. It inhibits CCK binding to peripheral-type receptor (CCK-A). Devazepide reverses the cholecystokinin octapeptide (CCK-8) based antagonism towards morphine.[4]

Características e benefícios

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informações de segurança

• Pictogramas: GHS06
• Palavra indicadora: Danger
• Frases de perigo: H300
• Declarações de precaução: P264 - P270 - P301 + P310 - P405 - P501
• Classificações de perigo: Acute Tox. 1 Oral
• Código de classe de armazenamento: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable