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D3658

Sigma-Aldrich

1,9-Dideoxyforskolin from Coleus forskohlii

≥97%, solid

Sinônimo(s):

7β-Acetoxy-6β-hydroxy-8,13-epoxy-labd-14-en-11-one

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R$ 988,00
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About This Item

Fórmula empírica (Notação de Hill):
C22H34O5
Número CAS:
64657-18-7
Peso molecular:
378.50
Número MDL:
MFCD00082318
Código UNSPSC:
41106305
ID de substância PubChem:
24893774
NACRES:
NA.77

R$ 988,00

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Ensaio

≥97%

Formulário

solid

atividade óptica

[α]26/D +93.6°, c = 6.12 in chloroform(lit.)

cor

white to off-white

solubilidade

methanol: 28 mg/mL(lit.)
DMSO: 3 mg/mL(lit.)
chloroform: 50 mg/mL
ethanol: 6.6 mg/mL(lit.)
dilute aqueous acid and base: insoluble(lit.)

temperatura de armazenamento

−20°C

cadeia de caracteres SMILES

[H][C@@]12[C@H](O)[C@H](OC(C)=O)[C@@]3(C)O[C@](C)(CC(=O)C3[C@@]1(C)CCCC2(C)C)C=C

InChI

1S/C22H34O5/c1-8-20(5)12-14(24)16-21(6)11-9-10-19(3,4)17(21)15(25)18(26-13(2)23)22(16,7)27-20/h8,15-18,25H,1,9-12H2,2-7H3/t15-,16?,17-,18-,20-,21+,22-/m0/s1

chave InChI

ZKZMDXUDDJYAIB-OJPJTMFRSA-N

Aplicação

Useful as a negative control for forskolin.

Ações bioquímicas/fisiológicas

Biologically inactive forskolin analog. Does not stimulate adenylyl cyclase.

Características e benefícios

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Adenylyl cyclases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

Eyeshields, Gloves, type N95 (US)

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Certificados de análise (COA)

Lot/Batch Number
0000315315
SLCQ3558
SLCP5906
SLCP8791
SLCP8790

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V Brès et al.
British journal of pharmacology, 130(8), 1976-1982 (2000-08-22)
To characterize the volume-sensitive, osmolyte permeable anion channels responsible for the osmodependent release of taurine from supraoptic nucleus (SON) astrocytes, we investigated the pharmacological properties of the [(3)H]-taurine efflux from acutely isolated SON. Taurine release induced by hypotonic stimulus (250
F Espinosa et al.
Developmental genetics, 25(2), 103-114 (1999-08-10)
The direct electrophysiological characterization of sperm Ca(2+) channels has been precluded by their small size and flat shape. An alternative to study these channels is to use spermatogenic cells, the progenitors of sperm, which are larger and easier to patch-clamp.
E X Albuquerque et al.
FEBS letters, 199(1), 113-120 (1986-04-07)
Forskolin, an activator of adenylate cyclase, and its analogs were studied on the nicotinic acetylcholine receptor-ion channel complex (AChR) of rat and frog skeletal muscles. At nanomolar concentrations, forskolin caused desensitization of the AChR located at the junctional region of
Jatinder Ahluwalia
Biochemical and biophysical research communications, 375(4), 596-601 (2008-08-30)
Effective functioning of neutrophils relies upon electron translocation through the NADPH oxidase (NOX). The electron current generated (I(e)) by the neutrophil NADPH oxidase is electrogenic and rapidly depolarises the membrane potential in activated human neutrophils. Swelling activated chloride channels have
Xunshan Ding et al.
The Journal of pharmacology and experimental therapeutics, 312(2), 849-856 (2004-10-02)
An extract of the plant Coleus forskohlii has been used for centuries in Ayurvedic medicine to treat various diseases such as hypothyroidism, heart disease, and respiratory disorders. Additionally, complex herbal mixtures containing this extract are gaining popularity in United States
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