C7971

Cilostamide

phosphodiesterase inhibitor

• Sinônimo(s): 6-[3-(N-Cyclohexyl-N-methylcarbamoyl)propoxy]quinolin-2[1H]-one, OPC 3689
• Fórmula empírica (Notação de Hill): C₂₀H₂₆N₂O₃
• Número CAS: 68550-75-4
• Peso molecular: 342.43
• Número MDL: MFCD00673958
• Código UNSPSC: 12352202
• ID de substância PubChem: 24278337
• NACRES: NA.77

Propriedades

• Ensaio: ≥97% (HPLC)
• Formulário: powder
• solubilidade: DMSO: 20 mg/mL, clear, colorless to faintly yellow
• cadeia de caracteres SMILES: CN(C1CCCCC1)C(=O)CCCOc2ccc3NC(=O)C=Cc3c2
• InChI: 1S/C20H26N2O3/c1-22(16-6-3-2-4-7-16)20(24)8-5-13-25-17-10-11-18-15(14-17)9-12-19(23)21-18/h9-12,14,16H,2-8,13H2,1H3,(H,21,23)
• chave InChI: UIAYVIIHMORPSJ-UHFFFAOYSA-N
• Informações sobre genes: human ... PDE3A(5139) , PDE3B(5140) , PDE5A(8654) , PDE7A(5150) ; rat ... Pde2a(81743) , Pde4a(25638)

Descrição

Ações bioquímicas/fisiológicas

PDE3 catalyzes the phosphodiester bond hydrolysis, observed in secondory messengers such as cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP). Inhibitors of PDE3 are generally inotropic and vasodilatory. They are being recognized for its use in treating heart failures.[1] Cilostamide is known to delay meiotic progression.[2]

Selective cGMP-inhibited phosphodiesterase inhibitor (PDE3); IC₅₀ = 70 ± 9 nM.

Selective inhibitor of PDE3 (cGMP-inhibited phosphodiesterase); IC₅₀ = 70 ± 9 nM. This inhibitory effect increases intracellular cAMP and inhibits platelet aggregation.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)