C3735
Cytochrome P450 human
1A1 Isozyme Microsomes, with P450 Reductase, recombinant, expressed in baculovirus infected insect cells (BTI-TN-5B1-4)
Faça loginpara ver os preços organizacionais e de contrato
About This Item
Número MDL:
Código UNSPSC:
12161501
NACRES:
NA.47
Preço e disponibilidade não estão disponíveis no momento.
Produtos recomendados
fonte biológica
human
Nível de qualidade
recombinante
expressed in baculovirus infected insect cells (BTI-TN-5B1-4)
Formulário
solution
atividade específica
≥4 units/pmol enzyme
peso molecular
45-60 kDa
embalagem
vial of 0.5 nmol
técnica(s)
activity assay: suitable
solubilidade
water: soluble
adequação
suitable for molecular biology
nº de adesão UniProt
aplicação(ões)
cell analysis
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
human ... CYP1A1(1543)
Procurando produtos similares? Visita Guia de comparação de produtos
Descrição geral
Research area: Immuno and CKS
Cytochrome P450 (CYP) enzymes are a family of enzymes that are encoded by the P450 genes. These enzymes are membrane bound hemoproteins. that are mainly found in the liver’s endoplasmic reticulum.
Cytochrome P450 (CYP) enzymes are a family of enzymes that are encoded by the P450 genes. These enzymes are membrane bound hemoproteins. that are mainly found in the liver’s endoplasmic reticulum.
Ações bioquímicas/fisiológicas
Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules, both as a function of intermediary metabolism (e.g., fatty acids) and to detoxify exogenous compounds (drugs or toxins). Some isoforms have narrow substrate specificity, while others are promiscuous. The CYP1A1 isoform catalyzes 7-deethylation of ethoxyresorufin. Cytochrome P450 (CYP) plays an important role in detoxifying xenobiotics, cellular metabolism and homeostasis. One of the main mechanisms of drug-drug interactions is the induction or inhibition of these enzymes. CYP enzymes are transcriptionally activated by a variety of xenobiotics and by endogenous substrates via receptor-dependent pathways. Inhibition of these enzymes is a major factor in metabolism-based drug-drug interactions, and many chemotherapeutic medications can cause drug interactions by either inhibiting or inducing the cytochrome p450 enzyme system.
forma física
Solution in 100 mM potassium phosphate buffer, pH 7.4.
Nota de preparo
Microsomes containing human CYP1A1 and recombinant human NADPH-P450 reductase.
Código de classe de armazenamento
12 - Non Combustible Liquids
Classe de risco de água (WGK)
WGK 2
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
Escolha uma das versões mais recentes:
Certificados de análise (COA)
Lot/Batch Number
Não está vendo a versão correta?
Se precisar de uma versão específica, você pode procurar um certificado específico pelo número do lote ou da remessa.
Já possui este produto?
Encontre a documentação dos produtos que você adquiriu recentemente na biblioteca de documentos.
Os clientes também visualizaram
Tomas Erban et al.
Biomedical chromatography : BMC, 26(9), 1062-1065 (2011-11-29)
A 96-well microplate-based HPLC endpoint assay is described for the determination of NADPH-cytochrome P450 reductase (CPR) activity. Novel sampling of NADPH into microplates was optimized. Separation was performed on a Zorbax Eclipse XDB-C₁₈ analytical 4.6 × 150 mm, 5 µm column. To validate the
Palrasu Manikandan et al.
Current drug targets, 19(1), 38-54 (2017-01-27)
The cytochrome P450 (CYP) enzymes are membrane-bound hemoproteins that play a pivotal role in the detoxification of xenobiotics, cellular metabolism and homeostasis. Induction or inhibition of CYP enzymes is a major mechanism that underlies drug-drug interactions. CYP enzymes can be
David Stucki et al.
Archives of biochemistry and biophysics, 687, 108383-108383 (2020-04-27)
Intracellular carbon monoxide (CO) is a gaseous signaling molecule and is generated enzymatically by heme oxygenases upon degradation of heme to billiverdin. Target structures for intracellular produced CO are heme proteins including cytochrome c oxidase of the respiratory chain, cytochrome
Moritz Walter et al.
Toxicology in vitro : an international journal published in association with BIBRA, 59, 215-220 (2019-04-21)
Next to its well-studied toxicity, carbon monoxide (CO) is recognized as a signalling molecule in various cellular processes. Thus, CO-releasing molecules (CORMs) are of considerable interest for basic research and drug development. Aim of the present study was to investigate
D P Bofinger et al.
Toxicological sciences : an official journal of the Society of Toxicology, 62(2), 299-314 (2001-07-14)
Endometriosis is a debilitating disease estimated to affect 10% of reproductive-age women and characterized by the growth of endometrial tissue outside of the uterus. The present study characterizes a human endometrial explant culture model for studying the direct effects of
Active Filters
Nossa equipe de cientistas tem experiência em todas as áreas de pesquisa, incluindo Life Sciences, ciência de materiais, síntese química, cromatografia, química analítica e muitas outras.
Entre em contato com a assistência técnica
