MTOXCE1A2
CypExpress™ 1A2 Cytochrome P450 human
Sinônimo(s):
CP12, CYP1A2, P3-450, P450 1A2, P450(PA)
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250 MG
R$ 1.499,00
1 G
R$ 3.381,00
10 G
R$ 25.446,00
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250 MG
R$ 1.499,00
1 G
R$ 3.381,00
10 G
R$ 25.446,00
About This Item
Produtos recomendados
fonte biológica
human
recombinante
expressed in Pichia pastoris
Formulário
dry powder
nº de adesão UniProt
aplicação(ões)
cell analysis
Condições de expedição
dry ice
temperatura de armazenamento
−70°C
Informações sobre genes
human ... CYP1A2(1544)
Aplicação
Poster: A Novel, Robust Recombinant Human P450 Biocatalytic System
Poster: Evaluation of Dry Powder Preparations of Permeabilized
Pichia pastoris Cells Expressing Human Cytochrome P450 2D6 Enzyme (CYP2D6) for Drug Metabolite Generation
Poster: Facile Scale-up Biocatalytic Production of P-450 Metabolites Using a Novel Recombinant Human Catalytic System
Poster: Multi-Cycle Production of Metabolites with human P450 systems
Poster: Rapid identifcation and production of metabolites using CypExpress™ 2D6m 3A4 and 2C9
Poster: Rapid identifcation and production of metabolites using stabilized dried powder (SDP) of human cytochrome P450S (hCYPS) 2D6, 3A4, and 2C9 engineered in yeast
Poster: Utilizing a Novel Biocatalytic Human P450 System for the Multi - Cycle Production of Metabolites
Poster: Evaluation of Dry Powder Preparations of Permeabilized
Pichia pastoris Cells Expressing Human Cytochrome P450 2D6 Enzyme (CYP2D6) for Drug Metabolite Generation
Poster: Facile Scale-up Biocatalytic Production of P-450 Metabolites Using a Novel Recombinant Human Catalytic System
Poster: Multi-Cycle Production of Metabolites with human P450 systems
Poster: Rapid identifcation and production of metabolites using CypExpress™ 2D6m 3A4 and 2C9
Poster: Rapid identifcation and production of metabolites using stabilized dried powder (SDP) of human cytochrome P450S (hCYPS) 2D6, 3A4, and 2C9 engineered in yeast
Poster: Utilizing a Novel Biocatalytic Human P450 System for the Multi - Cycle Production of Metabolites
Ações bioquímicas/fisiológicas
Cytochrome P450 enzymes are heme containing monooxygenases which are found primarily in the mammalian liver. They catalyze the oxidative metabolism of xenobiotics.[1][2][3][4] This metabolism is the initial step in the biotransformation and elimination of a wide variety of drugs and environmental pollutants from the body. Furafylline and α-naphthoflavone are inhibitors, whereas omeprazole and lansoprazole are inducers of the enzyme. The isozyme CYP1A2 is a major pathway for the in vivo conversion of phenacetin into acetaminophen via O-deethylation. This isozyme also catalyzes the 5-hydroxylation of thiabendazole.
Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules, both as a function of intermediary metabolism (e.g., fatty acids)[4] and to detoxify exogenous compounds (drugs or toxins).[3] Some isoforms have narrow substrate specificity, while others are promiscuous.
Cytochrome P450 is a heterogeneous family of isozymes whose primary function is to oxidize small molecules, both as a function of intermediary metabolism (e.g., fatty acids)[4] and to detoxify exogenous compounds (drugs or toxins).[3] Some isoforms have narrow substrate specificity, while others are promiscuous.
Características e benefícios
CypExpress™ 1A2 is a permeabilized and stabilized dried yeast powder preparation containing full length, unmodified, human CYP 1A2 and recombinant human NADPH oxidoreductase. Using proprietary processes, CypExpress™ are expressed in Pichia yeast. Following optimal expression, the cells are inactivated, permeabilized and dried to a fine powder. CypExpress™ retains the cellular mechanisms to provide the P450 enzymes with the energy and cofactors to continue to function for long experiments, and can generate larger amounts of metabolite than mammalian microsomes or other genetically engineered expression systems. It is designed for rapid screening of drug metabolites and for scaling up metabolite generation.
Definição da unidade
A reaction mixture containing 500 μM phenacetin and 100 mg/mL of CypExpress™ 1A2 will produce 35 μM acetaminophen in 4 hours at 30°C under the conditions described.
forma física
Light yellow, very fine powder
Reconstituição
Per Protocol/Variable
Informações legais
CypExpress is a trademark of Oxford Biomedical Research
Código de classe de armazenamento
11 - Combustible Solids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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R.Scott ObachA.S.Kalgutkar
Comprehensive Toxicology (2010)
Furafylline is a potent and selective inhibitor of cytochrome P450IA2 in man.
D Sesardic
British Journal of Clinical Pharmacology (1990)
Cytochrome P450 enzymes in drug metabolism and chemical toxicology: An introduction
Laura Lowe Furge and F. Peter Guengerich
Current Protocols in Cell Biology (2006)
Chapter 4 - Oxidant Stress, Antioxidant Defense, and Liver Injury
Mitchell R.McGill and HartmutJaeschke
Drug-Induced Liver Disease (2013)
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