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Merck
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Documentos

B3313

Sigma-Aldrich

Bicyclol

≥98% (HPLC)

Sinônimo(s):

4, 4′-dimethoxy-2, 3, 2′, 3′-bis(methylenedioxy)-6-hydroxymethyl-6′-methoxy-carbonyl biphenyl

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About This Item

Fórmula empírica (Notação de Hill):
C19H18O9
Número CAS:
118159-48-1
Peso molecular:
390.34
Número MDL:
MFCD00889471
Código UNSPSC:
12352202
ID de substância PubChem:
329773215
NACRES:
NA.77

Ensaio

≥98% (HPLC)

forma

powder

condição de armazenamento

desiccated

cor

white to off-white

solubilidade

DMSO: >10 mg/mL

temperatura de armazenamento

2-8°C

cadeia de caracteres SMILES

COC(=O)c1cc(OC)c2OCOc2c1-c3c(CO)cc(OC)c4OCOc34

InChI

1S/C19H18O9/c1-22-11-4-9(6-20)13(17-15(11)25-7-27-17)14-10(19(21)24-3)5-12(23-2)16-18(14)28-8-26-16/h4-5,20H,6-8H2,1-3H3

chave InChI

KXMTXZACPVCDMH-UHFFFAOYSA-N

Descrição geral

Bicyclol has anti-inflammatory properties and enhances the prognosis of kidney transplantation. It is involved in the removal of reactive oxygen species and modulates cytokine secretion.

Ações bioquímicas/fisiológicas

Bicyclol is a anti-hepatitis drug, used in China for chronic hepatitis B and presumably C. The drug appears to protect against liver injury in animals. Recently it was reported that bicyclol induce the expression of hepatic HSP27 and HSP70, and thus consequently inhibits the transcription factor NF-?B-mediated apoptosis and necrosis in liver tissue. It appears that bicyclol induces hepatic HSP27 and HSP70 expression through activating transcription of HSPs genes.

Pictogramas

Environment
GHS09

Palavra indicadora

Warning

Frases de perigo

H410

Declarações de precaução

P273 - P391 - P501

Classificações de perigo

Aquatic Acute 1 - Aquatic Chronic 1

Código de classe de armazenamento

11 - Combustible Solids

Classe de risco de água (WGK)

WGK 3

Ponto de fulgor (°F)

Not applicable

Ponto de fulgor (°C)

Not applicable

Equipamento de proteção individual

dust mask type N95 (US), Eyeshields, Gloves

Certificados de análise (COA)

Busque Certificados de análise (COA) digitando o Número do Lote do produto. Os números de lote e remessa podem ser encontrados no rótulo de um produto após a palavra “Lot” ou “Batch”.

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Effect of Bicyclol tablets on drug induced liver injuries after kidney transplantation
Shang W, et al.
Open Medicine : A Peer-Reviewed, Independent, Open-Access Journal, 12(1), 62-69 (2017)
Lijun Zhang et al.
International journal of biological macromolecules, 99, 63-70 (2017-02-09)
To study the characterization and hepatoprotective activity of polysaccharide from maca (Lepidium meyenii), the main polysaccharide from maca (MP-1) was obtained by DEAE-52 cellulose column. The average molecular weight of MP-1 was 1067.3kDa and the polysaccharide purity was 91.63%. In
Qinge Ma et al.
Journal of ethnopharmacology, 195, 166-172 (2016-11-15)
Houttuynia cordata is an important traditional Chinese medicine used in heat-clearing and detoxifying, swelling and discharging pus, promoting diuresis and relieving stranguria which recorded in Pharmacopoeia of the people's Republic of China (2015 Edition). H. cordata has been recorded in
Protective effect of bicyclol on acute alcohol-induced liver injury in mice
Zhao J, et al.
European Journal of Pharmacology, 586(1-3), 322-331 (2008)
Qinge Ma et al.
Bioorganic chemistry, 96, 103630-103630 (2020-02-10)
Chinese water chestnut, the bulb of Heleocharis dulcis, has been widely consumed as fruit or vegetable in China since ancient times. It exhibits health-promoting properties that leads to an extensive study of their active components. Successive chromatography of active fragments
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