A9501

Adenosine 3′,5′-cyclic monophosphate

≥98.5% (HPLC), powder, PKA activator

• Sinônimo(s): 3′,5′-Cyclic AMP, Adenosine 3′,5′-cyclophosphate, cAMP
• Fórmula empírica (Notação de Hill): C₁₀H₁₂N₅O₆P
• Número CAS: 60-92-4
• Peso molecular: 329.21
• Beilstein: 52645
• Número CE: 200-492-9
• Número MDL: MFCD00005845
• Código UNSPSC: 41106305
• eCl@ss: 32160414
• ID de substância PubChem: 24278245
• NACRES: NA.77

Propriedades

• product name: Adenosine 3′,5′-cyclic monophosphate, ≥98.5% (HPLC), powder
• Ensaio: ≥98.5% (HPLC)
• forma: powder
• cor: white
• pf: 260 °C (dec.) (lit.)
• solubilidade: H₂O: 10 mg/mL, clear, colorless (pH of aqueous solution is approx. 3.0. The sodium salt (A6885) is about 20× more soluble.)
• temperatura de armazenamento: −20°C
• cadeia de caracteres SMILES: Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O
• InChI: 1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
• chave InChI: IVOMOUWHDPKRLL-KQYNXXCUSA-N
• Informações sobre genes: human ... OPRK1(4986)

Descrição

Aplicação

Adenosine 3′,5′-cyclic monophosphate has been used:

• as cell culture medium supplement in embryonic spinal neurons
• as a component of ringer solution for perfusion studies
• to induce neuroendocrine differentiation in human lung cancer cell lines

Ações bioquímicas/fisiológicas

Naturally-occurring activator of cyclic-AMP-dependent protein kinase (PKA). cAMP is an important second messenger that is linked in many systems to neurotransmitter- or hormone-induced receptor stimulation. The cAMP/PKA signaling pathway has been shown to inhibit cell proliferation, induce differentiation and lead to apoptosis.

Características e benefícios

This compound is a featured product for ADME Tox and Cyclic Nucleotide research. Discover more featured ADME Tox and Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Informações de segurança

• Código de classe de armazenamento: 11 - Combustible Solids
• Classe de risco de água (WGK): WGK 3
• Ponto de fulgor (°F): Not applicable
• Ponto de fulgor (°C): Not applicable
• Equipamento de proteção individual: Eyeshields, Gloves, type N95 (US)