The reconstituted product is stable for 1 month at –20 °C and for at least 2 months at –70 °C. Product 528205, a prepared solution, also stored at -70°C, is assigned a retest schedule of every two years. See the link below to review this product page:
https://www.sigmaaldrich.com/US/en/product/mm/528205
A8111
Plasminogen activator inhibitor 1 (PAI-1)
≥200,000 units/mg protein, lyophilized powder, ≥90% (SDS-PAGE)
Sinônimo(s):
PAIE, PLANH1, Plasminogen activator inhibitor, β-migrating endothelial cell-derived type, Serpin E1 PAI-1, Serpine 1
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25 μG
R$ 2.143,00
R$ 2.143,00
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25 μG
R$ 2.143,00
About This Item
R$ 2.143,00
Check Cart for Availability
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Nome do produto
Plasminogen activator inhibitor 1 (PAI-1) human, recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
recombinante
expressed in E. coli
Nível de qualidade
Ensaio
≥90% (SDS-PAGE)
Formulário
lyophilized powder
atividade específica
≥200,000 units/mg protein
peso molecular
~43 kDa
solubilidade
water: 0.1 mL, clear, colorless
nº de adesão UniProt
Condições de expedição
dry ice
temperatura de armazenamento
−20°C
Informações sobre genes
human ... SERPINE1(5054)
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Descrição geral
Aplicação
Plasminogen activator inhibitor 1 (PAI-1) human has been used:
- as an inhibitor of pro-brain-derived neurotrophic factor (proBDNF) in radioimmunoprecipitation assay (RIPA) in peripheral blood and lymphocytes[3]
- to block plasmin activation in mice infected with C. albicans hyphae[4]
- to test its effect on neurite growth in neurons[5]
Ações bioquímicas/fisiológicas
Plasminogen Activator Inhibitor 1 (PAI-1) protein belongs to the Serpin superfamily of serine protease inhibitors. It is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), the activators of plasminogen and therefore inhibits the fibrinolysis process. PAI is involved in extracellular matrix remodeling and has been implicated in processes like angiogenesis, chemotaxis, ovulation, and embryogenesis. PAI-1 is present in increased levels in various disease states such as a number of cancer forms, obesity and the metabolic syndrome.
Plasminogen activator inhibitor 1 (PAI-1), a member of the Serpin superfamily of serine protease inhibitors, is involved in extracellular matrix remodeling and implicated in processes like angiogenesis, chemotaxis, ovulation, and embryogenesis.
Definição da unidade
1 unit irreversibly inhibits (100% inhibition) 1 unit of tissue plasminogen activator (tPA) under physiological conditions (neutral pH and 37 ºC).
forma física
Supplied as a lyophilized powder from a solution containing 0.5 M sodium chloride, 20 mM sodium acetate, and 50 mg/mL trehalose.
Reconstituição
Reconstitute to 0.25 mg/ml with ultrapure water. The reconstituted product contains 0.25 mgP/mL in 0.5 M sodium chloride, 20 mM sodium acetate, and 50 mg/mL trehalose.
Nota de análise
The product is the active human PAI-1 protein with a molecular weight of 43 kDa.
Código de classe de armazenamento
10 - Combustible liquids
Classe de risco de água (WGK)
WGK 1
Ponto de fulgor (°F)
Not applicable
Ponto de fulgor (°C)
Not applicable
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Matteo Cesari et al.
Cardiovascular therapeutics, 28(5), e72-e91 (2010-07-16)
The close relationship existing between aging and thrombosis has growingly been studied in this last decade. The age-related development of a prothrombotic imbalance in the fibrinolysis homeostasis has been hypothesized as the basis of this increased cardiovascular and cerebrovascular risk.
Kirwin M Providence et al.
Archives of dermatological research, 300(6), 303-310 (2008-04-04)
Cutaneous tissue injury, both in vivo and in vitro, initiates activation of a "wound repair" transcriptional program. One such highly induced gene encodes plasminogen activator inhibitor type-1 (PAI-1, SERPINE1). PAI-1-GFP, expressed as a fusion protein under inducible control of +800
William Santus et al.
Science immunology, 2(15) (2017-09-25)
Nuclear factor of activated T cells (NFAT) is activated in innate immune cells downstream of pattern recognition receptors, but little is known about NFAT's functions in innate immunity compared with adaptive immunity. We show that early activation of NFAT balances
Sadiya S Khan et al.
Science advances, 3(11), eaao1617-eaao1617 (2017-11-21)
Plasminogen activator inhibitor-1 (PAI-1) has been shown to be a key component of the senescence-related secretome and a direct mediator of cellular senescence. In murine models of accelerated aging, genetic deficiency and targeted inhibition of PAI-1 protect against aging-like pathology
Liying Lin et al.
Journal of psychiatric research, 133, 166-173 (2020-12-21)
Previous studies showed that blood BDNF levels in mood disorders were reduced. However, little is known about the changes of BDNF and its precursor proBDNF in lymphocytes. In addition, earlier studies using commercial ELISA kits cannot distinguish mature BDNF from
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Lipid Induced Insulin Resistance
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Once it has been reconstituted, what is the recommended storage temperature? Will the reconstituted liquid be stable at 4 C for short-term storage (e.g. <24 hrs)?
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